The objective of this study was to investigate the effect of Mycobacterium vaccae on Jagged 1 and gamma delta T17 (gdT17) cells in asthmatic mice. An asthma mouse model was established through immunization with ovalbumin (OVA). Gammasecretase inhibitor (DAPT) was used to block the Notch signaling pathway. M. vaccae was used to treat asthma, and related indicators were measured. Blocking Notch signaling inhibited the production of gdT17 cells and secretion of cytokine interleukin (IL)-17, which was accompanied by a decrease in Jagged1 mRNA and protein expression in the treated asthma group compared with the untreated asthma group. Similarly, treatment with M. vaccae inhibited Jagged1 expression and gdT17 cell production, which was associated with decreased airway inflammation and reactivity. The Notch signaling pathway may play a role in the pathogenesis of asthma through the induction of Jagged1 receptor. On the other hand, the inhibitory effect of M. vaccae on Jagged1 receptor in gdT17 cells could be used for the prevention and treatment of asthma.
In order to reduce the vast total harmonic distortion (THD) caused by hysteresis loop space vector control strategy in three-phase Voltage Source Rectifier (VSR), an optimized strategy based on fuzzy rules is proposed in the paper. In the new strategy, a current error vector threshold value was pre-set. When the actual current error value is less than the threshold, the hysteresis loop space vector control strategy will be adopted to reduce the switching frequency and loss. However, when the current error value is larger than the threshold, the optimized hysteresis loop control strategy based on fuzzy rules will be adopted to achieve the fast current tracking. Based on the new strategy, the simulation model has been established and simulated by matlab/simulink. And the results show that the optimized control strategy not only ensures the fast dynamic response with low switching frequency, but also reduces the current THD significantly. Finally, the feasibility and the superiority of the optimized strategy based on fuzzy rules have been further verified under a 1kW experiment system.
The model and simulation of three-phase Two-level Grid-connected Photovoltaic System are established. According to the equivalent circuit and mathematical model of the PV cell, the general simulation model of photovoltaic array is established. Regulating duty ratio in Boost circuit to realize the maximum power point tracing with method of high-precision incremental conductance. Model of photovoltaic inverter is established based on power decoupling vector control strategy. SVPWM modulation improves the utilization ratio of voltage in DC side. Finally, the simulation of three-phase two-level grid-connected photovoltaic system is conducted in MATLAB. The result shows that the system can rapidly and accurately track maximum power point and the output of current keep in the same frequency and phase, which can be connected to power grid flexibly.
The scene is considered as the management foothold of production, technology, quality, equipments, safety, and environment for workshop. Optimizing the scene management is not only a necessity for enhancing diathesis and strengthening development ability, but also a consciousness of strengthening the management involvement of employees. Therefore, scientific optimization of scene management is an inevitable requirement for promoting the overall management level.
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