Abstract. Chitosan(CS) is the unique alkaline polysaccharide in nature, because of its perfect biocompatibility and degradability, it is widely used in medicine, soft release and control release. The betulinic acid is the derivative of betulin, it has many pharmacological activities, such as anti-inflammatory, antitumor, anti-malaria and anti-HIV. In this paper, the Span-80 was used as emulsifiers, the glutaraldehyde was used as crosslinker. With the method of orthogonal experiment, the preparation technology was optimized. The microspheres were characterized by SEM and its degree of crosslinking, drug-loading rate and encapsulation efficiency were tested at the same time.
The phase inversion process is a kind of efficient technology of emulsifying, it make its emulsifying ability to maximize by the means of control the factors of the HLB, the concentration of emulsifier, the ratio of emulsifier and oil and the temperature of emulsify. In this paper, the epoxy resin E-44 and polyethylene glycol used as materials, potassium persulfate as the catalytic agent, then we obtained the waterborne epoxy resin emulsion. The synthetic conditions of emulsifier, the mechanical stability and water-solubility of the emulsion were researched. Then the optimal amount of the emulsifier was determined and the modified emulsion was characterized, the particle size and viscosity were tested at the same time.
Chitosan (CS) is an important slow-release carrier of drugs and fertilizers. The pure chitosan have poor performance, it should be added to a certain amount of crosslinking agents, emulsifiers and porogenic agents to improve the performance of it. The advantage of montmorillonite is no pollution and no toxicity, composite material filled in montmorillonite has an excellent mechanical properties. In this article, CS/MMT/ACAP drug-loading microsperes was prepared with the CS, ACAP and MMT as the main raw materials by emulsification-crosslinking method. Orthogonal experiment was designed to optimize the preparation process of the CS/MMT/ACAP drug-loading microspheres. FT-IR, XRD and SEM were applied to characterize the structure and morphology of microspheres. The sustained release effect of CS/MMT/ACAP microsphere was measured by sustained release measurement. The results show that the CS/MMT/ACAP drug-loading micropheres were successfully prepared by emulsification-crosslinking method. The microspheres assumed a good sphericity and a uniform particle size distribution; the drug-loading microspheres had good sustained release effect.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.