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With the advent of the era of precision medicine, prostate‐specific membrane antigen (PSMA)‐targeted theranostic strategies have had a profound impact on prostate cancer research. As a specific membrane antigen target, PSMA is not only widely expressed in prostate cancer tissues but its expression is also correlated with tumor aggressiveness. Because of the noninvasiveness, real‐time nature, high sensitivity, and low side effects of phototheranostics, in recent years, there has been a rapid advancement in PSMA‐targeted phototheranostics, such as near‐infrared fluorescence imaging and imaging‐guided surgical navigation, photoacoustic imaging, dual‐modality hybrid imaging and imaging‐guided surgical navigation, photodynamic therapy, and photothermal therapy. Herein, the design and application of various types of imaging probes and photosensitizers based on PSMA targeting developed in the past two decades are reviewed, with a focus on molecular design strategies for near‐infrared fluorescent probes and hybrid tracers. In addition, the challenges of and future opportunities for the clinical translation of phototheranostics in the field of prostate cancer are discussed.

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Compared with unbalance forces and moments of four- and six-cylinder engines, forces and moments applied to the engine block from a three-cylinder engine are large and the mechanism for balancing the unbalance forces are complex. So design of a mounting system for the powertrain with a three-cylinder engine is more challenging. This paper presents the analytical methods for obtaining the unbalance forces and moments applied to the engine block for a three-cylinder engine with or without balance measures, and develops a design methodology for the Powertrain Mounting System with a three-cylinder engine. The unbalance forces and moments generated by cylinders, crank and connecting rod mechanisms and applied to the engine block are analyzed firstly. Then, three balance methods for reducing the forces and moments applied to the engine block are proposed and discussed. Three balance measures are described and analyzed. The methods for estimating forces and moments applied to the engine block under the three balance measures are developed and compared. Thirdly, an optimization method is proposed to estimate mount stiffness based on minimization of mount forces transmitted to the car body or sub-frame, along with meeting requirements for placing natural frequencies of the powertrain in prescribed ranges and those for maximizing modal energy distributions of the powertrain in six directions. An example is given to validate the calculation methods and design philosophy for the mounting system of a powertrain with a three-cylinder engine.

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Elastomeric isolators are used in a variety of different applications to reduce noise and vibration. Using isolators effectively requires the product design and development engineer to satisfy multiple objectives, which typically include packaging restrictions, environmental criteria, limitations on motion control, load requirements, and minimum fatigue life, in addition to vibration isolation performance. An understanding of elastomeric material properties and the methods used to characterize elastomeric component behavior is necessary to achieve desired performance. Typical design criteria and functional objectives for various isolator applications, including powertrain mounts, suspension control arm bushings, shock‐absorber bushings, exhaust hangers, flexible couplings, cradle mounts, body mounts, and vibration dampers are also discussed.