ZnS-coated CdSe composite particles have been continuously synthesized in a microfluidic reactor. By using this system, CdSe particles and a ZnS coating can be produced in sequence, and the particle size and layer thickness can be directly adjusted by the residence time. It demonstrated that the continuous synthesis in the microreactor was a simple and efficient way to prepare composite particles with different structures and determine the optimized experimental conditions.
Highly efficient light-harvesting systems with the sequential energy transfer process are significant for utilizing solar energy in photosynthesis. Herein, we report a quadrilateral platinum(II) metallacycle containing tetraphenylethylene (M1) as a lightharvesting platform. The M1 assembly serves as an ideal donor because of the aggregation-induced emission (AIE) effect, realizing two-step sequential energy transfer from the M1 assembly to eosin Y (ESY) and then to sulforhodamine (SR101) with high efficiency. ESY was used as a bridge in a relay mode during this process. To better mimic natural photosynthesis, the M1−ESY− SR101 system was utilized as photochemical catalysis for alkylation of C−H bonds in aqueous solution, showing enhanced catalytic activity as compared with the M1−ESY system or ESY/SR101 alone.
Figure 1: Applications using cubic mean value coordinates. Left: shape deformation using curved cage networks, (a,b): input images, (c,d): deformed results. Right: an adaptive gradient mesh (g) created from a given gradient mesh (e), and (f,h) are the rasterized images of (e,g).
Background: Hepatocellular carcinoma (HCC) is a highly fatal malignant cancer worldwide. Elucidating the underlying molecular mechanism of HCC progression is critical for the identification of new therapeutic targets for HCC. This study aimed to determine the role of Non-SMC condensin II complex subunit G2 (NCAPG2) in HCC proliferation and metastasis. Methods: We detected NCAPG2 expression in tissues using immunohistochemistry, western blotting and realtime PCR. The effects of NCAPG2 on cell proliferation and metastasis were evaluated both in vitro and in vivo. Immunocytochemistry, enzyme linked immunosorbent assay, co-immunoprecipitation and luciferase reporter assay were performed to uncover the underlying mechanisms. Findings: We found that NCAPG2 is frequently upregulated in HCC tumour tissues and predicts a poor prognosis. NCAPG2 overexpression promotes HCC proliferation, migration, and invasion through activating STAT3 and NF-κB signalling pathways. Moreover, NCAPG2 is a direct target of miR-188-3p. We demonstrated the existence of a positive feedback loop between NCAPG2 and p-STAT3 and a negative feedback loop between NCAPG2 and miR-188-3p. Interpretation: Our study indicates that NCAPG2 overexpression could drive HCC proliferation and metastasis through activation of the STAT3 and NF-κB/miR-188-3p pathways. These findings may contribute to the identification of novel biomarkers and therapeutic targets for HCC.
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