Rational design and understanding of the intrinsic mechanism are critical to develop highly active and durable electrocatalysts. In this study, a series of bi-metallic boride catalysts based on Ni and Co were prepared, and their activities were evaluated. The synthesised Co-10Ni-B catalyst exhibited excellent activity for water splitting in a 1 M KOH electrolyte. The overpotential was 330 mV at a current density of 10 mA cm-2, better than previously reported mono-metallic borides and even IrO2. The synergistic effect of Co and Ni was proved by X-ray photoelectron spectroscopy and electrochemical impedance spectroscopy. The facile formation of critical intermediates CoOOH and NiOOH during the catalytic processes and a significant increase in surface area owing to the introduction of a second metal into mono-metallic boride were attributed to the superior catalytic performance of catalysts for the oxygen evolution reaction. A Co-10Ni-B-sp catalyst with a higher surface area than the Co-10Ni-B catalyst was also synthesised to evaluate the effect of a high surface area on the catalytic activity. A lower overpotential of 310 mV at a current density of 10 mA cm-2 was achieved.
Forsythiaside, a phenylethanoside product isolated from air-dried fruits of Forsythia suspensa, has been demonstrated to exhibit antioxidant, antibacterial and anti-inflammatory activities in vitro. However, its mechanism and the effects of lipopolysaccharide (LPS)-induced injury on the bursa of Fabricius (BF) of chickens are poorly understood. The present study aimed to investigate the anti-inflammatory effects of forsythiaside on LPS-induced acute inflammation. In addition, the potential molecular mechanisms of forsythiaside were analyzed in the BF, a special immune organ in chickens. Forty 15-day-old chickens were randomly divided into control, LPS and LPS plus forsythiaside (30 or 60 mg/kg) groups (n=10 for each group). In the LPS plus forsythiaside (30 or 60 mg/kg) groups, the chickens were orally administered with forsythiaside at doses of 30 and 60 mg/kg for seven days. At 21 days old, the chickens were intravenously injected with 200 μg/kg body weight LPS. Chickens in the control and LPS groups were only administered with vehicle or LPS, respectively, at day 21. At 3 h post-injection, the body temperature and nitric oxide (NO) levels were analyzed. In addition, the levels and mRNA expression of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-1β, and the mRNA expression of nuclear factor-κB (NF-κB), cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS), were examined in the BFs isolated from the chickens. The results revealed that forsythiaside was able to attenuate the LPS-induced inflammatory responses in the BFs of the chickens. The mechanisms by which forsythiaside exerted its anti-inflammatory effect were found to correlate with the inhibition of IL-6, IL-1β, TNF-α and COX-2 production, via the inactivation of NF-κB, indicating that the NF-κB-iNOS-NO signaling pathway may be important in this process.
Many approaches have been proposed for publishing useful information while preserving data privacy. Among them, the privacy models of identity-reserved (k, l)-anonymity and identityreserved (α, β)-anonymity have been proposed to handle the situation where an individual could have multiple records. However, the two models fail to prevent attribute disclosure. To this end, we propose two new privacy models: enhanced identity-reserved l-diversity and enhanced identity-reserved (α, β)-anonymity. Moreover, to implement the two privacy models we design a general anonymization algorithm, called DAnonyIR, with clustering technique by calling different decision functions, which can decrease the information loss caused by generalization. Further, we compare DAnonyIR concerning our two privacy models with existing generalization method GeneIR concerning identity-reserved (k, l)-anonymity and identity-reserved (α, β)-anonymity, respectively. The experimental results show that our two approaches provide stronger privacy preservation, and their information loss and relative error ratio of query answering are less than those of GeneIR.
NEAT1 is an important tumor oncogenic gene in various tumors. Nevertheless, its involvement remains poorly studied in cervical cancer. Our study explored the functional mechanism of NEAT1 in cervical cancer. NEAT1 level in several cervical cancer cells was quantified and we found NEAT1 was greatly upregulated in vitro. NEAT1 knockdown inhibited cervical cancer development through repressing cell proliferation, colony formation, capacity of migration, and invasion and also inducing the apoptosis. For another, microRNA (miR)‐133a was downregulated in cervical cancer cells and NEAT1 negatively modulated miR‐133a expression. Subsequently, we validated that miR‐133a functioned as a potential target of NEAT1. Meanwhile, SOX4 is abnormally expressed in various cancers. SOX4 was able to act as a downstream target of miR‐133a and silencing of SOX4 can restrain cervical cancer progression. In addition, in vivo assays were conducted to prove the role of NEAT1/miR‐133a/SOX4 axis in cervical cancer. These findings implied that NEAT1 served as a competing endogenous RNA to sponge miR‐133a and regulate SOX4 in cervical cancer pathogenesis. To sum up, it was implied that NEAT1/miR‐133a/SOX4 axis was involved in cervical cancer development.
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