A removable
acyl group promoted the intramolecular didehydro-Diels–Alder
reaction of styrene-ynes under mild reaction conditions is proposed.
The reaction is free of metals and catalysts, is easy to perform,
and exhibits good functional group tolerance, providing a highly chemoselective
approach for obtaining the valuable aryldihydronaphthalene derivatives.
A novel and convenient K 2 S 2 O 8 -mediated diiodo cyclization of 1,6-enynes for the facile synthesis of functionalized γlactam derivatives has been developed. This reaction features mild and transition-metal-free conditions, which offer a green and efficient entry to synthetically important γ-lactam scaffolds. Mechanistic studies suggest that iodide radicals initiate the cascade cyclic transformation.
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