A Pd/norbornene/Cu cooperative catalysis for the efficient synthesis of 2-(arylthio)aryl ketones from aryl halides and thioesters has been developed. The first example of cooperative catalysis by palladium, norbornene, and copper, wherein the C(O)-S bond of thioesters is cleaved by a Pd(II) palladacycle with the assistance of CuI, has been observed.
A Pd-catalyzed chemoselective Catellani reaction of iodopyrroles was developed. The rare chemoselectivity between two different aryl halides was realized by optimizing the kinetics of the different steps of this multicomponent process. The new developed method led to the rapid synthesis of rhazinal in a highly efficient manner.
Three-component cross-coupling cocatalyzed
by palladium and norbornene
is reported for the synthesis of biaryl atropisomers. This domino
reaction gave optimal yield and enantioselectivity with a P,C-type
ligand bearing axial chirality and P chiral center. The process showed
advantages over traditional cross-coupling because of its step economy
and its compatibility with readily available ortho-substituted aryl halides, which could, therefore, be used instead
of continuously trisubstituted aryl halides.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.