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In this study, supercritical fluid extraction with carbon dioxide was applied to achieve a successful extraction of both β-carotene and α-tocopherol from pumpkin.

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The nanoscale drug-loaded micelles can be prepared by the supercritical carbon dioxide evaporation method. Here, response surface methodology is used to optimize this process. The effects of pressure, ScCO2 release rate and the volume ratio of water against ScCO2 on the drug entrapment efficiency (EE) of the obtained micelles are discussed in detail. The obtained second-order polynomial equation can successfully predict the drug EE of the drug-loaded micelles. The maximum EE can reach 70.1% under optimal conditions in which the pressure is 12.27 MPa, the release rate is 10 L min−1 and the volume ratio of water against ScCO2 is 3.67:1. The prepared micelles exhibit a narrow size distribution and relatively regularly spherical shape. In vitro drug release study reveals that the release of paclitaxel from the micelles is slow and sustained.

Background: Hyperopia is a common blurred vision phenomenon that affects postural control in gait; however, current research has focused on the alteration and correction of hyperopia’s physiological characteristics, ignoring the effect of hyperopia on gait kinematic characteristics. The effect of hyperopia on the basic form of movement walking is a worthy concern.Objective: To investigate the gait kinematic characteristics of male college students with varying degrees of visual acuity (normal vision, hyperopia 150°, and hyperopia 450°), as well as to provide a theoretical foundation for the effect of visual acuity on gait and fall risk reduction.Methods: Twenty-two male college students with normal visual acuity were chosen. Their vision was tested using a standard visual acuity logarithm table at normal and with 150° and 450° concave lenses. Gait kinematic data were collected under normal vision and hyperopic conditions using the PN3 Pro advanced inertial motion capture system and Axis Studio application program.Results and conclusion: 1. The change of center of gravity in Pre-double support was smaller than normal vision; Late-single support and Late-swing was larger than normal vision; 2. The percentage of the double-leg support decreased; the percentage of the single-leg support and the Late-swing increased; 3. For the joints’ range of motion, Trunk flexion and extension range of motion in Pre-single support, Late-double support and Pre-swing smaller than normal visual acuity, and Late-swing larger than normal; hip internal abduction and adduction and internal and external rotation are larger than normal vision in Late-single support; knee and ankle in abduction and adduction direction are larger than normal vision in the swing stage; hip flexion and extension, internal external rotation are larger than normal vision in the swing stage. Hyperopic interventions have an impact on the kinematic characteristics of gait in male college students, mainly in terms of altered balance, increased instability, increased difficulty in maintaining trunk stability, and increased risk of injury.