Background: Prediabetes is an intermediate state in which blood glucose is higher than normal but does not meet the diagnostic criteria for diabetes. Diffusion tensor imaging (DTI) is an MRI method that can sensitively detect microscopic lesions in the white matter of the brain, but most previous DTI studies only focused on patients with diabetes, and little is known about prediabetes. Purpose: To investigate the changes in the microstructure of brain white matter in prediabetes patients using DTI and trace-based spatial statistics (TBSS). Study Type: Prospective. Population: Sixty subjects (30 patients with prediabetes and 30 healthy volunteers) were enrolled. Field Strength/Sequence: 3.0T/DTI-MRI sequence with single-shot echo-planar imaging sequence (SE-EPI). Assessment: DTI data were collected and analyzed using the TBSS method in the FMRIB software library. Statistical Tests: DTI using a two-sample t-test. Pearson correlation analysis was performed on DTI values and neuropsychology scale results (mini-mental state examination [MMSE], Montreal cognitive assessment [MoCA], self-rating anxiety scale [SAS], and self-rating depression scale [SDS]) Results: Compared with the control group, the fractional anisotropy (FA) values in the right part of the corpus callosum body (bCC) (P = 0.035), the right superior longitudinal fasciculus (SLF.R) (P = 0.047), and the left superior longitudinal fasciculus (SLF.L) in the prediabetic group were reduced (P = 0.040). Data Conclusion: DTI as a noninvasive technique can assess early changes in the white matter microarchitecture of patients with prediabetes. Level of Evidence: 2 Technical Efficacy: Stage 2

Using computed tomography myocardial perfusion imaging (CTP) to investigate resting myocardial perfusion alterations in uncomplicated type 2 diabetes mellitus (T2DM) patients without obstructive coronary artery disease (CAD).A total of 34 participants with 544 myocardial segments were included prospectively: 17 uncomplicated T2DM patients with no significant coronary artery stenosis on coronary computed tomography angiography and 17 healthy controls. Myocardial perfusion was evaluated by transmural perfusion ratio (TPR). Parameters of cardiac structure and function were measured for cardiac comprehensive assessment. Analyses included descriptive statistics and group comparisons.TPR of segments 5, 7, 9, 10 to 14 were significantly reduced in T2DM group compared with controls (P < .05). When 16 myocardial segments were localized into different areas according to the wall orientations, axial levels of left ventricle and coronary artery territories, respectively, TPR of each area in T2DM group were significantly lower than those in the control group (P < .05). No significant differences were found in cardiac anatomy and function analyses between 2 groups.In uncomplicated T2DM patients without obstructive CAD, myocardial perfusion impairments were present and may develop prior to cardiac morphological and functional abnormalities, which can be early detected by CTP.

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