Mirabegron increases human atrial force through β - but not β -adrenoceptors. Desipramine and phenoxybenzamine block neuronal uptake and conceivably prevent mirabegron from releasing noradrenaline. A non-specific cardiodepressant effect is not mediated through β (or β )-adrenoceptors, consistent with lack of β -adrenoceptor function on human atrial contractility.
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