Objective: This paper briefly reviews the structure and function of NLRP3 inflammasomes, signaling pathway, relationship with synovitis in KOA, and intervention of traditional Chinese medicine (TCM) in NLRP3 inflammasomes as a means to improve its therapeutic potential and clinical application.Method: Literatures about NLRP3 inflammasomes and synovitis in KOA were reviewed to analyze and discuss.Result: NLRP3 inflammasome can activate NF-κB mediated signal transduction, which in turn causes the expression of proinflammatory cytokines, initiates the innate immune response, and triggers synovitis in KOA. The TCM monomer/active ingredient, decoction, external ointment, and acupuncture regulating NLRP3 inflammasomes are helpful to alleviate synovitis in KOA.Conclusion: The NLRP3 inflammasome plays a significant role in the pathogenesis of synovitis in KOA, TCM intervention targeting the NLRP3 inflammasome can be a novel approach and therapeutic direction for the treatment of synovitis in KOA.
Introduction: Kummell disease is also known as vertebral fracture nonunion, delayed vertebral collapse and vertebral ischemic necrosis. It often occurs in a delayed manner after spinal injury, and is a complex and rare spinal disease. This study, aimed to report a case of stage 3 Kummell disease, diagnosed using magnetic resonance imaging (MRI) of the lumbar spine.Methods: The subject underwent a short-segment fixation of the pedicle screw combined with kyphoplasty.Results: The patient was satisfied with the relief of back pain after the surgery, but the surgery was found to cause screw cutting vertebrae in the second lumbar vertebra (L2).Conclusion: Short-segment fixation of the pedicle screw combined with kyphoplasty can reconstruct spinal stability, maintain stability of bone cement mass in vertebrae, correct kyphosis deformity, and relieve pain. However, Kummell disease in elderly patients is always accompanied by severe osteoporosis. The common fixation of the pedicle screw is prone to cause screw cutting, loosening, and pulling out. Therefore, we advocate using cement-augmented pedicle screws.
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