Background : Nimotuzumab is a humanized anti-epidermal growth factor receptor (EGFR) antibody that has shown preclinical and clinical anticancer activity in cerebral glioblastoma multiforme (GBM). We conducted a phase II, single-arm, multicenter clinical trial to evaluate the benefit of adding nimotuzumab to current standard chemo-radiotherapy for patients with GBM with positive EGFR expression. Methods : Newly diagnosed patients with histologically proven single supratentorial GBM and epidermal growth factor receptor (EGFR) positive expressions were recruited. All patients were treated with nimotuzumab, administered once a week intravenously for 6 weeks in addition to radiotherapy with concomitant and adjuvant temozolomide after surgery. The primary endpoints were overall survival (OS) and progression-free survival (PFS). Secondary objectives included objective response rate (ORR) and toxicity. Results : A total of 39 patients were enrolled and 36 patients were evaluated for efficacy. The ORR at the end of RT was 72.2%. Median OS and PFS were 24.5 and 11.9 months. The 1-year OS and PFS rates were 83.3% and 49.3%. The 2-year OS and PFS rates were 51.1% and 29.0%. O (6)-methylquanine DNA methyl-tranferase (MGMT) expression is known to affect the efficacy of chemotherapy and status of its expression is examined. No significant correlation between treatment outcomes and MGMT status was found. Most frequent treatment-related toxicities were mild to moderate and included constipation, anorexia, fatigue, nausea, vomiting, and leucopenia. Conclusions : Our study show that nimotuzumab in addition to standard treatment is well tolerable and has increased survival in newly diagnosed GBM patients with EGFR positive expression.
The reductive alkylation of p-nitroaniline with 5-methyl-2-hexanone over copper-based catalysts was investigated. Furthermore, the catalysts were characterized using the techniques of XRD, H 2 -N 2 O titration, H 2 -TPR, NH 3 -TPD and pyridine-FTIR. The results showed that the addition of Mn, Ba and La into Cu-SiO 2 catalyst played an important role in the improvement of the selectivity towards N,N 0 -bis(1,4-dimethylpentyl)-p-phenylenediamine (BMPPD). The highest selectivity towards BMPPD over 58CuO-9MnO 2 -BaO-1La 2 O 3 -30SiO 2 (wt.%) catalyst could be ascribed to the best dispersion of copper (i.e., the highest hydrogenation ability) and the most amounts of the surface Lewis acidic sites.
Owing to low cost, excellent pressure and corrosion resistance, bimetallic lined pipes were regarded as one of the most important methods to resolve corrosion of traditional steel pipes used for oilfield. Nowadays, the pipes are widely used in the projects of oil and gas gathering and transportation. However, there were some failure cases in succession in recent years. In this paper, the failure causes were excavated from multiple perspectives, and on this basis further countermeasures were put forward. Firstly, three typical failure accidents, including CRA layer collapse, CRA layer corrosion and weld joint failure, were listed throughout the whole life cycle from product ordering, construction technology to later operation. Secondly, failure analysis was carried out from five aspects: product quality, test technology, welding process, standard specification and application threshold, and a serial of comprehensive views were proposed. 1) Manufacturing period: Water seepage and tightness between CRA layer and backing pipe could not be effectively monitored. The ratio of collapse test was low so that proposed relevant risk could not be eliminated; 2) Welding period: the process has high risk failure in theory and lack of process assessment and construction acceptance standards. Potential danger could not be effectively assessed, and weld quality could not be guaranteed; 3) Application period: The CRA application range remained unclear, and bimetallic lined pipes were used in the environment beyond the threshold sometimes. The paper also summarized further improvement measures and research directions about these five aspects, including process quality, inspect technique, welding process, standard specification and application range. Finally, solution suggestions were proposed for the whole chain from manufacturers, testing institutions, construction units to oilfield users.
It is well known that welding technique was often a knotty problem for bimetallic lined steel pipes to use widely. A number of failures in secession of weld cracking and weld corrosion had been observed in oil fields in recent years, which seriously disrupted the order of oil and gas production. To solve welding problems of 316L bimetallic lined pipes, works outcome about failure analysis and welding process research were presented in this paper. Failure analysis results confirmed that Welding defects, high hardness regions was the main reasons about failure problems of weld crack while structure design defects of seal weld and bad back-protection effects of flux-cored wire resulted in weld corrosion. Welding defects in the regions of seal weld became the failure source while the high hardness both in the region of seal weld and weld joint formed the crack propagation channel, and therefore both initially contributed to weld cracking. Additionally owing to the structure design of seal weld, liner layer would be heated over and over again during the period of seal weld and then it was not enough to protect CRA layers from being damaged during the period of girth weld. As a result the corrosion resistance in the welding area was reduced to become a weak area. On the basis of failure analysis, further research work was carried out to improve welding performance. Seal weld structure and girth weld process was improved. The difference of welding wires and welding process was analyzed, and their defects were described separately. Results showed that the welding performance welding by ERNiCrMo-3 and supporting technology was more reliable than ATS-F309L and supporting technology, whether seal weld or butt welding. The distribution and value of the hardness could be effectively controlled; Moreover, corrosion resistance performance was also better. Therefore, the seal weld and girth weld conducted by ERNiCrMo-3 and supporting technology was feasible.
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