Danggui Buxue Tang (DBT) is a simple combination of Radix and Radix (5:1), with a variety pharmacological activities. In the present study, a single intravenous injection of 30 mg/kg streptozotocin and subsequent six weeks of high glucose diet in Sprague Dawley rats were used to induce diabetic nephropathy. Rats with diabetes mellitus showed increased levels of fasting blood glucose (FBG), blood urea nitrogen (BUN), serum creatinine (Scr), serum and urine β2-microglobulins (β2-MG), and type IV collagen (all P<0.05). DBT treatment significantly decreased the levels of FBG, BUN, Scr, serum and urine β2-MG, and type IV collagen. Furthermore, DBT treatment significantly and dose-dependently restored the ultrastructural injury, and reduced the expression of heparanase, compared with the vehicle (P<0.05). Therefore, DBT may be a novel therapeutic approach for the prevention and treatment of diabetic nephrology.
Water eutrophication due to the discharge
of nitrogen-containing
wastewater has aroused widespread concern around the world, and photocatalysis
is confirmed a promising method to dispose the problem. Nonetheless,
co-degradation of ammonia nitrogen and nitrate nitrogen is still nerve-wracking.
In this work, the Ag3PO4@Ag4V2O7 Z-scheme photocatalysts with a micro-nano tube-cluster
structure were designed by a facile in situ growth method, which realized
concurrent removal of nitrate and ammonia in wastewater, without the
addition of hole scavengers or electron scavengers, due to its high
redox ability. The experimental results demonstrated that P@V1 composites
showed superior rate (2.79 times enhancement) and higher conversion
(3.00 times enhancement) compared with the pure Ag4V2O7 crystals for ammonia degradation and the pure
Ag3PO4 crystals for nitrate reduction, respectively.
Therefore, Z-scheme photocatalysts offer a new thought for co-degradation
of low concentrations of nitrogenous contaminated water.
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