The synthesis of benzimidazoles by intermolecular cyclization reaction of 2-iodoanilines with nitriles has been developed. These reactions proceeded without the aid of any transition metals or ligands and just using KOBu(t) as the base. A variety of substituted benzimidazole derivatives can be synthesized by the approach.
A tandem one-pot method for the direct synthesis of polysubstituted triphenylene 2,3-dicarboxylic esters with different substitution patterns was developed by enyne metathesis of diarylacetylene, followed by Diels-Alder, aromatization and a cyclization cascade.
A Convenient Tandem One-Pot Synthesis of Donor-Acceptor-Type Triphenylene 2,3-Dicarboxylic Esters from Diarylacetylene. -A new strategy for the direct synthesis of donor-acceptor-type triphenylene 2,3-dicarboxylic esters in a one-pot manner through a cascade reaction involving enyne metathesis of diarylacetylene, cycloaddition with a dienophile, and subsequent aromatization and oxidative cyclodehydrogenation is developed. This can be considered as a simple alternative that may offer access to more complicated triphenylene-based molecules with different substitution patterns. -(FENG, C.; TIAN, X.-L.; ZHOU, J.; XIANG, S.-K.; YU, W.-H.; WANG*, B.-Q.; HU, P.; REDSHAW, C.; ZHAO, K.-Q.; Org. Biomol. Chem. 12 (2014) 36, 6977-6981, http://dx.
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