Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) is an Epstein-Barr virus (EBV)-associated cutaneous T/NK cell lymphoproliferative disease that mainly affects children and adolescents. 1 Classic hydroa vacciniforme (HV) is characterized by papulovesicular eruptions that evolve into crusts and heal with pitted scars in sunexposed areas. Systemic symptoms, including fever, lymphadenopathy, and hepatosplenomegaly, are absent. Atypical or severe HV has mainly been reported in East Asia and Latin America. These patients present with more progressive skin eruptions, such as marked facial edema, necrosis, or large ulcers, which usually extend to non-sunexposed areas and are accompanied by systemic symptoms. 2 2 | B RIEF REP ORT This retrospective study was performed at the Affiliated Children's Hospital and the First Affiliated Hospital of Chongqing Medical University.Thirty-two patients evaluated from 2013 to 2020 were included (Table 1). Patients included 17 females and 15 males, ranging from 1.5 to 21 years (median: 8 years) at time of diagnosis.Thirty-four biopsies of skin lesions from 32 patients were analyzed. Epidermal vesicles, ulcers, and necrosis were observed, with varying degrees of small-to medium-sized polymorphic lymphocytes infiltrating the dermis and subcutaneous fat, with a predominantly perivascular and periadnexal distribution.
There are elevated levels of superoxide anion in non‐neuronal cells and neurons within prevertebral sympathetic ganglia of desoxycorticosterone acetate salt hypertensive (HT) rats. We hypothesized that the non‐neuronal cells were satellite cells (SCs) and we used glial fibrillary acidic protein (GFAP) as a marker for them in the celiac ganglion (CG). Using a polyclonal primary antibody for GFAP, we compared GFAP expression in the CG of the normotensive (NT) and HT rat. GFAP marked two populations of non‐neuronal cells: 1) SCs closely approximated to neurons; 2) small cells widely distributed in intercellular spaces. GFAP‐immunoreactive SCs associated with neurons were counted and their number was compared between NT and HT. The ratio of immunoreactive (IR) SCs to total SCs was greater in HT (p<.005, n=88‐130 SCs) compared to NT. The number of IR SCs per neuron was greater in HT (p<.05, n=29 neurons). There was no difference in the total number of SCs per neuron (p>.05, n=29 neurons) between NT and HT. These results show that the number of perineuronal SCs is not greater in HT but rather more SCs are expressing GFAP in ganglia from HT rats. Support: HL70687.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.