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[1] The global ionospheric map (GIM) is used to observe variations in the total electron content (TEC) of the global positioning system (GPS) associated with 35 M ! 6.0 earthquakes that occurred in China during the 10-year period of 1 May 1998 to 30 April 2008. The statistical result indicates that the GPS TEC above the epicenter often pronouncedly decreases on day 3-5 before 17 M ! 6.3 earthquakes. The GPS TEC of the GIM and electron density profiles probed by six microsatellites of FORMOSAT3/ COSMIC (F3/C) are further employed to simultaneously observe seismoionospheric anomalies during an M w 7.9 earthquake near Wenchuan, China, on 12 May 2008. It is found that GPS TEC above the forthcoming epicenter anomalously decreases in the afternoon period of day 6-4 and in the late evening period of day 3 before the earthquake, but enhances in the afternoon of day 3 before the earthquake. The spatial distributions of the anomalous and extreme reductions and enhancements indicate that the earthquake preparation area is about 1650 km and 2850 km from the epicenter in the latitudinal and longitudinal directions, respectively. The F3/C results further show that the ionospheric F 2 peak electron density, N m F 2 , and height, h m F 2 , significantly decreases approximately 40% and descends about 50-80 km, respectively, when the GPS TEC anomalously reduces.

To verify the pre-earthquake ionospheric anomaly (PEIA), statistical analyses are implemented on the relationship between the total electron content (TEC) of global ionosphere map (GIM) and 62 M ≥ 6.0 earthquakes in China during 1998 -2015. A median-based method together with z test is employed to determine the criteria and/or characteristics of TEC anomalies related to earthquakes. , 18 -20 days before 7 M ≥ 7.0 earthquakes. The receiver operating characteristic (ROC) curve is used to compare the TEC anomaly-based method with some competitive alternatives for predicting the earthquakes under study. We found, based on possible TEC anomalies, that the observed PEIAs are significantly earthquake-related. Moreover, the results of regression analyses show that the PEIA strength is associated with the magnitude of earthquakes.

Pulmonary hypertension (PH) is an increasingly recognized complication of systemic lupus erythematosus (SLE). To develop a more comprehensive understanding of the clinical and pathological characteristics of pulmonary hypertension associated with systemic lupus erythematosus (PH/SLE) in the Chinese population, a systematic review of the literature up to 2012 was conducted. Six hundred and forty-two Chinese PH/SLE cases from 22 studies were identified as well documented and further analyzed. Transthoracic echocardiography (TTE), X-ray, electrocardiogram and right heart catheterization (RHC) were performed to diagnose PH in SLE patients. The mean age of subjects was 35.5 years, the male to female ratio was 1:14, and the mean duration of SLE when PH was diagnosed was 10.7 years. The prevalence of PH in SLE was 2.8–23.3 %. Symptoms were usually nonspecific, and the observed clinical characteristics include Raynaud’s phenomenon (41.4 %), serous effusion (27.7 %), positive RNP (51.5 %) and positive ACL (46.6 %). Gold standard RHC is strongly recommended, especially for those who had resting pulmonary arterial systolic pressure >30 mmHg on TTE with the aforementioned clinical characteristics. Corticosteroids, immunosuppressants and vasodilators were the most common medications employed in treatment. Early identification and standard PH treatment with intensive SLE treatment can improve the prognosis.

Abstract. The imminent prediction on a group of strong earthquakes that occurred in Xinjiang, China in April 1997 is introduced in detail. The prediction was made on the basis of comprehensive analyses on the results obtained by multiple innovative methods including measurements of crustal stress, observation of infrasonic wave in an ultra low frequency range, and recording of abnormal behavior of certain animals. Other successful examples of prediction are also enumerated. The statistics shows that above 40% of 20 total predictions jointly presented by J. Z. Li, Z. Q. Ren and others since 1995 can be regarded as effective. With the above methods, precursors of almost every strong earthquake around the world that occurred in recent years were recorded in our laboratory. However, the physical mechanisms of the observed precursors are yet impossible to explain at this stage.

To quantitatively evaluate in the laboratory the effect of soil temperature on bare soil evaporation, this study uses two indoor soil columns and homogenized sand as an example to carry out the experimental study of soil temperature on bare soil evaporation in winter. The results show that the soil temperature directly affects the change in bare soil evaporation and that the effect decreases as the soil temperature decreases. Because of the influence of soil temperature, the soil water movement accelerates, and the soil water content increases. At a depth of 50 cm, the average difference in soil water content between groups A and B was 7.61%. The soil evaporation when considering the soil temperature was obviously greater than that without considering the soil temperature. This shows that in a laboratory environment where the soil temperature is higher than the room temperature in winter, the effect of the soil temperature on bare soil evaporation is significant. Soil temperature directly affects soil water movement and distribution, which is one of the important influencing factors affecting bare soil evaporation.

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Iron plays a critical role in immune responses. However, its role in T helper cell differentiation and function remains poorly understood. In this study, it is shown that the restraint of iron availability through blocking CD71‐mediated iron endocytosis impaired the differentiation and pathogenicity of TH17 cells. Administrations of anti‐CD71 mAb could relieve the development of experimental autoimmune encephalomyelitis (EAE). Mechanistically, the iron deficiency due to the blocking of CD71 enhanced IL‐2 expression, which further restrained the differentiation of TH17 cells. Meanwhile, CD71 blockade impaired histone modifications of Il17 gene and reduced the recruitment of RORγt to Il17a locus. In sum, the findings reveal that iron plays a pivotal role in regulating TH17 cell differentiation and function in autoimmune diseases.