The relationships between multiple visual rating scales based on structural magnetic resonance imaging (sMRI) with disease severity and cerebrospinal fluid (CSF) biomarkers in patients with Alzheimer’s disease (AD) were ambiguous. In this study, a total of 438 patients with clinically diagnosed AD were recruited. All participants underwent brain sMRI scan, and medial temporal lobe atrophy (MTA), posterior atrophy (PA), global cerebral atrophy-frontal sub-scale (GCA-F), and Fazekas rating scores were visually evaluated. Meanwhile, disease severity was assessed by neuropsychological tests such as the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Clinical Dementia Rating (CDR). Among them, 95 patients were tested for CSF core biomarkers, including Aβ1–42, Aβ1–40, Aβ1–42/Aβ1–40, p-tau, and t-tau. As a result, the GCA-F and Fazekas scales showed positively significant correlations with onset age (r = 0.181, p < 0.001; r = 0.411, p < 0.001, respectively). Patients with late-onset AD (LOAD) showed higher GCA-F and Fazekas scores (p < 0.001, p < 0.001). With regard to the disease duration, the MTA and GCA-F were positively correlated (r = 0.137, p < 0.05; r = 0.106, p < 0.05, respectively). In terms of disease severity, a positively significant association emerged between disease severity and the MTA, PA GCA-F, and Fazekas scores (p < 0.001, p < 0.001, p < 0.001, p < 0.05, respectively). Moreover, after adjusting for age, gender, and APOE alleles, the MTA scale contributed to moderate to severe AD in statistical significance independently by multivariate logistic regression analysis (p < 0.05). The model combining visual rating scales, age, gender, and APOE alleles showed the best performance for the prediction of moderate to severe AD significantly (AUC = 0.712, sensitivity = 51.5%, specificity = 84.6%). In addition, we observed that the MTA and Fazekas scores were associated with a lower concentration of Aβ1–42 (p < 0.031, p < 0.022, respectively). In summary, we systematically analyzed the benefits of multiple visual rating scales in predicting the clinical status of AD. The visual rating scales combined with age, gender, and APOE alleles showed best performance in predicting the severity of AD. MRI biomarkers in combination with CSF biomarkers can be used in clinical practice.
Objective: To investigate the status quo of nursing practice environment, nurses’ safety attitude, and occupational well-being, as well as to explore the relationship among the three, so as to provide reference for formulating and implementing corresponding measures. Methods: A cross-sectional survey was conducted from October 2021 to December 2021. A total of 1,939 nurses from five tertiary hospitals in a city were surveyed using the Nurses’ Practice Environment Assessment Scale, Safety Attitudes Questionnaire, and Medical Workers’ Occupational Wellbeing Scale. The data were analyzed using SPSS 22.0. Results: The total score of nurses’ practice environment was 68.81 ± 27.79 points, which is at a relatively general level; the total score of nurses’ safety attitude was 111.28 ± 14.38 points, which is at a moderate level; and the total score of occupational well-being was 62.43 ± 28.17 points, which is relatively high. There was a significant positive correlation between nurses’ practice environment and their safety attitudes and occupational well-being (p < 0.05). Conclusion: Nurses are the main human resources in hospitals, and their practice environment is closely related to patient safety and their work enthusiasm. An unhealthy practice environment not only affects the quality of care, which leads to patient safety issues, but also their job satisfaction. Nurse managers are encouraged to implement targeted interventions in advance to improve nurses’ practice environment, strengthen safety attitudes, and enhance the professional wellbeing of nurses.
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