Solid‐state transistor sensors that can detect biomolecules in real time are highly attractive for emerging bioanalytical applications. However, combining upscalable manufacturing with the required performance remains challenging. Here, an alternative biosensor transistor concept is developed, which relies on a solution‐processed In 2 O 3 /ZnO semiconducting heterojunction featuring a geometrically engineered tri‐channel architecture for the rapid, real‐time detection of important biomolecules. The sensor combines a high electron mobility channel, attributed to the electronic properties of the In 2 O 3 /ZnO heterointerface, in close proximity to a sensing surface featuring tethered analyte receptors. The unusual tri‐channel design enables strong coupling between the buried electron channel and electrostatic perturbations occurring during receptor–analyte interactions allowing for robust, real‐time detection of biomolecules down to attomolar (a m ) concentrations. The experimental findings are corroborated by extensive device simulations, highlighting the unique advantages of the heterojunction tri‐channel design. By functionalizing the surface of the geometrically engineered channel with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) antibody receptors, real‐time detection of the SARS‐CoV‐2 spike S1 protein down to a m concentrations is demonstrated in under 2 min in physiological relevant conditions.
With the rapid developments of the Industrial Era 4.0, numerous sensors have been employed to facilitate and monitor the quality of machining processes. Among them, accelerometers play an important role in chatter detection and suppression for reducing the tool down-time and increasing manufacturing efficiency. To date, most commonly seen accelerometers have relatively large sizes such that they can be installed only on the housing of spindles or the surfaces of workpieces that may not be able to directly capture actual vibration signals or obstruct the cutting process. To address this challenge, this research proposed a compact, wide-bandwidth resonant accelerometer that could be embedded inside high-speed spindles for real-time chatter monitoring and prediction.Composed of a double-ended tuning fork (DETF), a proof mass, and a support beam, the resonant accelerometer utilizes the resonance frequency shift of the DETF due to the bending motions of the structure during out-of-plane accelerations as the sensing mechanism. The entire structure based on commercially available quartz tuning forks (QTFs) with electrodes for symmetric-mode excitations. The advantages of this structure include low noise and wide operation bandwidth thanks to the frequency modulation scheme. A theoretical model and finite element analysis were conducted for designs and optimizations. Simulated results demonstrated that the proposed accelerometer has a size of 9.76 mm × 4.8 mm × 5.5 mm, a simulated sensitivity of 0.94 Hz/g, and a simulated working bandwidth of 3.5 kHz. The research results are expected to be beneficial for chatter detection and intelligent manufacturing.Micromachines 2020, 11, 42 2 of 11 highly reliable, and low-cost sensors are in high demand in the era of the internet of things (IoT). The commonly used accelerometer transducer mechanisms include capacitive [8], piezoresistive [9], and piezoelectric [10,11] mechanisms, all of which produce an output voltage or charge proportional to the measured acceleration. While capacitive and piezoresistive transducers suffer from a relatively weak mechanical-electrical conversion efficiency and a higher power consumption, respectively, piezoelectric transducers surpass the other two mechanisms with a higher transducer efficiency and no standby power. For a typical piezoelectric accelerometer, acceleration will cause the proof mass to exert a force on the beam or film, creating a charge due to piezoelectric effect. However, most resonant type accelerometers have relatively large sizes and are usually installed on the housing of spindles or the stage of workpiece holders.The goal of this research is to design a compact, resonant-type accelerometer for chatter detections. In general, the rotation speed of high-speed spindles can be as high as 30,000 rpm (i.e., 500 Hz), and chatter frequencies usually occur near the operation frequencies with several harmonics. For chatter detections, the working bandwidth of a measuring accelerometer should be 7 times the operation frequency, which is ...
Solid-state transistor sensors that can detect biomolecules in real time are highly attractive for emerging bioanalytical applications. However, combining cost-effective manufacturing with high sensitivity, specificity and fast sensing response, remains challenging. Here we develop low-temperature solution-processed In2O3/ZnO heterojunction transistors featuring a geometrically engineered tri-channel architecture for rapid real-time detection of different biomolecules. The sensor combines a high electron mobility channel, attributed to the quasi-two-dimensional electron gas (q2DEG) at the buried In2O3/ZnO heterointerface, in close proximity to a sensing surface featuring tethered analyte receptors. The unusual tri-channel design enables strong coupling between the buried q2DEG and the minute electronic perturbations occurring during receptor-analyte interactions allowing for robust, real-time detection of biomolecules down to attomolar (aM) concentrations. By functionalizing the tri-channel surface with SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) antibody receptors, we demonstrate real-time detection of the SARS-CoV-2 spike S1 protein down to attomolar concentrations in under two minutes.
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