A one-pot, effective synthesis of pyridines by a modified Kröhnke procedure is described. Polysubstituted annulated pyridines were synthesized in high yields by four-component, one-pot cyclocondensation reactions of N-phenacylpyridinium bromide, aromatic aldehydes, acetophenones or cyclic ketones in the presence of ammonium acetate and acetic acid, assisted by microwave irradiation. In this procedure, cyclic ketones with two alpha-CH(2) groups yield annulated pyridines with additional alpha-benzylidene groups, which are derived in situ from double aldol condensation of cyclic ketones with two moles of aromatic aldehydes.

No abstract

The simple procedure affords polysubstituted and annulated pyridines. Advantages are the short reaction time, simple experimental procedures and product isolation. -(YAN*, C.-G.; CAI, X.-M.; WANG, Q.-F.; WANG, T.-Y.; ZHENG, M.; Org. Biomol. Chem. 5 (2007) 6, 945-951; Coll. Chem.

No abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

WU, P.; CAI, X.-M.; WANG, Q.-F.; YAN*, C.-G.; Synth. Commun. 41 (2011) 6, 841-850, http://dx.doi.org/10.1080/00397911003706990 ; Coll. Chem. Chem. Eng., Yangzhou Univ., Yangzhou, Jiangsu 225002, Peop. Rep. China; Eng.) -M. Bohle 32-041

No abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.