Neutrophilic epitheliotropism is a new sensitive and specific histopathological clue for NUD, a histopathological reaction pattern within the spectrum of neutrophilic dermatoses that needs to be differentiated from conventional urticaria.

Background:The clinical impact of increased torsion on patellar instability and patellofemoral pain syndrome (PFPS) has been suggested by several studies.Hypothesis:The hypotheses of this study were that (1) torsional malalignment (TM) is characterized by a positive correlation between different malalignment parameters that represent an overall picture of the malalignment syndrome and (2) an increase in overall torsion is the underlying difference between patellar instability and isolated patellofemoral pain.Study Design:Cohort study; Level of evidence, 3.Methods:Between April 2015 and July 2017, a total of 428 patients were treated for lateral patellar dislocation (LPD), and 333 patients were treated for PFPS. Sixty-two patients (14.5%) with patellar instability (LPD group) and 29 patients (8.7%) with patellofemoral pain (PFPS group) had additional TM and were included in this study. All patients underwent magnetic resonance imaging for torsional alignment and patellar tracking, including femoral antetorsion, tibial torsion, knee rotation, tibial tuberosity–trochlear groove (TT-TG) distance, tibial tuberosity–posterior cruciate ligament (TT-PCL) distance, Dejour classification of trochlear dysplasia, lateral trochlear inclination (LTI) angle, and patellar height.Results:The LPD and PFPS groups differed significantly in terms of trochlear dysplasia (P < .001), LTI angle (P < .001), and TT-TG distance (P = .0167) but did not differ in terms of femoral antetorsion (20.02° ± 8.80° vs 20.03° ± 7.91°, respectively; P = .8545), tibial torsion (39.53° ± 9.23° vs 41.24° ± 7.28°, respectively; P = .3616), or knee rotation (10.42° ± 5.16° vs 8.48° ± 7.81°, respectively; P = .0163). Only measures of TT-TG distance and TT-PCL distance and measures of TT-TG distance and knee rotation were positively correlated. Trochlear dysplasia (type B-D) was identified as the only significant predictor of patellar instability.Conclusion:TM in patients with either PFPS or LPD does not appear to be characterized by a fixed constellation of different malalignment parameters. Between groups, the parameters differed significantly only in terms of trochlear dysplasia and the TT-TG distance, and trochlear dysplasia (type B-D) (but not torsion) was identified as a predictor of lateral patellar instability.

Background The precise clinical diagnosis of Parkinson's disease (PD) can be difficult in the early stages. Diagnostic criteria include the response of key motor features to levodopa as a supportive prospective criterion. Data are sparse on the diagnostic value of the acute levodopa challenge test (LDCT) in patients with de novo PD. The objective of this study was to validate the LDCT as a tool in the early clinical diagnosis of PD. Methods We performed the standardized LDCT with 250 mg levodopa in the prospective longitudinal cohort study “DeNoPa,” comprising 159 patients with de novo PD, and carried out longitudinal clinical follow‐up for 24 months. Motor assessments at baseline using the motor part (part III) of the Unified Parkinson's Disease Rating Scale before and 1 hr after drug administration were documented. The optimal cutoff score on the LDCT was calculated using the Youden index. Results Clinical reassessment of 144 patients who returned for follow‐up confirmed the diagnosis of PD in 120 patients (83%). In 24 patients (17%), the initial diagnoses were revised and classified as other neurologic disorders. The optimal cutoff at 33% improvement of motor symptoms on the part 3 of the Unified Parkinson's Disease Rating Scale during the LDCT reached a sensitivity of 70% a specificity of 71%. The positive and negative predictive values were 92% and 32%, respectively. Sensitivity (91%), specificity (79%), and positive/negative (96%/63%) predictive values improved with the addition of further clinical information (urinary incontinence, fainting, asymmetric tremor, and amount of further drug‐intake). Conclusions The LDCT is a reliable tool in the early diagnosis of PD. The accuracy of this test can be further improved by additional, easy‐to‐acquire clinical information provided by patients. © 2017 International Parkinson and Movement Disorder Society.

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