Plant secondary metabolites exhibit several biological applications and becoming great attention, recently [1]. People utilize enormous therapeutic medicinal plants for various human ailments and proved as novel resource of bioactive compounds as antimicrobial agent for more than centuries [2]. In general, the antimicrobial agent is a chemical or physical agent which control or even kill the microorganisms. And also, it disturbs the growth and reproduction of microorganisms such as bacteria, fungi, parasites and viruses. Of them, fungi like Aspergillus fumigatus and Candida albicans have capability to cause life-threatening systemic infections [3,4]. Moreover, bacteria causes following poultry diseases such as, Escherichia coli infections, salmonelloses, paratyphoid infections, fowl cholera, riemerella Anatipestifer infections, Mycoplasma, necrotic enteritis, cholangiohepatitis in broiler chickens, gangrenous dermatitis, botulism, avian tuberculosis. The fungi, Aspergillus fumigatus causes Aspergillosis (Fungal Pneumonia) in poultry while Orthomyxo virus produce Avian influenza. Several causative agents such as, Mycoplasma synoviae, Staphylococcus aureus, E.coli and certain reoviruses are causes infectious synovitis. Respiratory viruses and E. coli induce Mycoplasma gallicepticum. Aspergillosis is an acute or chronic respiratory disease, Aspergillus Granulomatous Dermatitis as a postvaccinal complication which observed in growing broiler breeders, Aflatoxicosis, Candidiasis, Fusariotoxicoses. Omphalitis (navel infection) is characterized with reddening and tissue oedema in the umbilical region [5].Furthermor, diarrhea associated with E. coli take place in young piglets within a few days of birth through well after weaning. Occasional cases of septicemia are attributable to E. coli [6]. Colibacillosis is a disease caused by the bacterium E. coli, which normally resides in the lower intestines of most warm blooded mammals, including dogs. It is a common disease in poultry and systemic infection occurs when large numbers of Avian Pathogenic E. Coli (APEC) gain access to the bloodstream from the respiratory tract or intestine [7,8]. Bacteremia progresses to septicemia and death, or the infection extends to serosal surfaces, pericardium, joints, and other organs. Infected cattle seem to be the most frequent source of infection, although buffalos, goats, sheep and camels can also pass on the bacteria [9]. Milk production is associated with agriculture for the reason that farmers nurture the live stocks in villages. Though dairying associated with agriculture, milk is consumed by only rich sector