This paper investigates the appropriate range of values for the transcutaneous blood oxygen saturation (S t O 2 ) of granulating tissues and the surrounding tissue that can ensure timely wound recovery. This work has used a multispectral imaging system to collect wound images at wavelengths ranging between 520 nm and 600 nm with a resolution of 10 nm. As part of this research, a pilot study was conducted on three injured individuals with super¯cial wounds of di®erent wound ages at di®erent skin locations. The S t O 2 value predicted for the examined wounds using the Extended Modi¯ed Lambert-Beer model revealed a mean S t O 2 of 61 AE 10:3% compared to 41:6 AE 6:2% at the surrounding tissues, and 50:1 AE 1:53% for control sites. These preliminary results contribute to the existing knowledge on the possible range and variation of wound bed S t O 2 that are to be used as indicators of the functioning of the vasomotion system and wound health. This study has concluded that a high S t O 2 of approximately 60% and a large°uctuation in this value should precede a good progression in wound healing.
This work presents the use of extended Modi¯ed Lambert Beer (MLB) model for accurate and continuous monitoring of percent blood carboxyhemoglobin (COHb) (SCO) and oxyhemoglobin (OxyHb) saturation (SO 2 ) via a¯tting procedure. This quanti¯cation technique is based on the absorption characteristics of hemoglobin derivatives in the wavelength range of 520-600 nm to give the best estimates of the required parameters. A comparison of the performance of the developed model and MLB law is made using attenuation data from Monte Carlo simulations for a two-layered skin model. The results revealed a lower mean absolute error of 0:4% in the values estimated by the developed model as compared to 10% that is given by the MLB law. This study showed that the discussed approach is able to provide consistent and accurate measurement of blood SO 2 and SCO across di®erent skin pigmentations suggesting that it may potentially be used as an alternative means for clinical diagnosis of carbon monoxide (CO) poisoning.
Noninvasive measurement of health parameters such as blood oxygen saturation and bilirubin concentration predicted via an appropriate light reflectance model based on the measured optical signals is of eminent interest in biomedical research. This is to replace the use of conventional invasive blood sampling approach. This study aims to investigate the feasibility of using Modified Lambert Beer model (MLB) in the prediction of one’s bilirubin concentration and blood oxygen saturation value, SO2. This quantification technique is based on a priori knowledge of extinction coefficients of bilirubin and hemoglobin derivatives in the wavelength range of 440 – 500 nm. The validity of the prediction was evaluated using light reflectance data from TracePro raytracing software for a single-layered skin model with varying bilirubin concentration. The results revealed some promising trends in the estimated bilirubin concentration with mean ± standard deviation (SD) error of 0.255 ± 0.025 g/l. Meanwhile, a remarkable low mean ± SD error of 9.11 ± 2.48 % was found for the predicted SO2 value. It was concluded that these errors are likely due to the insufficiency of the MLB at describing changes in the light attenuation with the underlying light absorption processes. In addition, this study also suggested the use of a linear regression model deduced from this work for an improved prediction of the required health parameter values.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.