Human telomeric RNA performs various cellular functions such as telomere length regulation, heterochromatin formation, and chromosome end protection. Using a combination of nuclear magnetic resonance, circular dichroism, and gel electrophoresis, we observed an unusual topological structure formed by human telomere RNA r(GUUAGGGU). Our results showed that every set of four strands formed a parallel G-quadruplex as symmetry-related units containing four G-tetrads, two U-tetrads, and one A-tetrad. An eight-stranded helical fragment containing A-, G-, and U-tetrads provided a central intercalated scaffold that connected two G-quadruplex units in an alternating antiparallel arrangement, giving rise to a novel RNA architecture. This higher order RNA structure is so stable that it would be surprising if similar structures do not occur in nature. Our findings provide a new insight into the behavior of human telomeric RNA molecules.

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structure structure (organic substances) K 9000 -031Methyl 7α,12α-Dihydroxy-3α-methacryloyloxy-5β-cholan-24-oate. -The structure of synthetic title compound (I) is determined by X-ray analysis with a view to the synthesis of new polymers with potential biomedical and pharmaceutical applications. -(LIU, H.; BELANGER-GARIEPY, F.; AKRAM, M.; MOSKOVA, M.; ZHU, X.-X.; Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 54 (1998) 6, 801-803; Dep. Chem., Univ. Montreal, Montreal, Que. H3C 3J7, Can.; EN)

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