Our manuscript was based on surveillance cases of COVID-19 identified before January 26, 2020. As of February 20, 2020, the total number of confirmed cases in mainland China has reached 18 times of the number in our manuscript. While the methods and the main conclusions in our original analyses remain solid, we decided to withdraw this preprint for the time being, and will replace it with a more up-to-date version shortly. Should you have any comments or suggestions, please feel free to contact the corresponding author.
Silica has the highest demonstrated potential of any phase to preserve microfossils on Earth and therefore may host potential biosignatures on Mars. We detected hydrated silica in Jezero crater, the landing site of the National Aeronautics and Space Administration's Mars 2020 rover mission, by applying Dynamic Aperture Factor Analysis/Target Transformation to images from the Compact Reconnaissance Imaging Spectrometer for Mars. Hydrated silica detections with Dynamic Aperture Factor Analysis/Target Transformation were verified using commonly accepted Compact Reconnaissance Imaging Spectrometer for Mars analysis methods. The morphology of geologic units associated with silica was characterized with high‐resolution imaging. Several hypotheses are presented for the formation environment of hydrated silica. All are testable via in situ investigation. We assess the likelihood of silica to preserve biosignatures in these different scenarios based on habitability considerations and biosignature preservation in Earth analog environments and materials. Also reported are possible detections of hydrated silica in the Nili Fossae basement and olivine‐rich units, as well as Al‐phyllosilicate within Jezero crater.
Unmanipulated haploidentical/mismatched related transplantation with combined granulocyte-colony stimulating factor-mobilised peripheral blood stem cells (G-PBSCs) and granulocyte-colony stimulating factor-mobilised bone marrow (G-BM) has been developed as an alternative transplantation strategy for patients with haematologic malignancies. However, little information is available about the factors predicting the outcome of peripheral blood stem cell (PBSC) collection and bone marrow (BM) harvest in this transplantation. The effects of donor characteristics and procedure factors on CD34+ cell yield were investigated. A total of 104 related healthy donors received granulocyte-colony stimulating factor (G-CSF) followed by PBSC collection and BM harvest. Male donors had significantly higher yields compared with female donors. In multiple regression analysis for peripheral blood collection, age and flow rate were negatively correlated with cell yield, whereas body mass index, pre-aphaeresis white blood cell (WBC) and circulating immature cell (CIC) counts were positively correlated with cell yields. For BM harvest, age was negatively correlated with cell yields, whereas pre-BM collection CIC counts were positively correlated with cell yield. All donors achieved the final product of ≥6 ×106 kg−1 recipient body weight. This transplantation strategy has been shown to be a feasible approach with acceptable outcomes in stem cell collection for patients who received HLA-haploidentical/mismatched transplantation with combined G-PBSCs and G-BM. In donors with multiple high-risk characteristics for poor aphaeresis CD34+ cell yield, BM was an alternative source.
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