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ABSTRACT.Although it is known that parental carriers of structural chromosomal rearrangements are associated with recurrent pregnancy loss, subsequent natural pregnancies remain possible. We examined the reproductive outcome of a familial balanced translocation with t(3;6) (q12;q27). Karyotyping of the proband revealed 46,XY chromosomes with the balanced translocation t(3;6). The first 2 pregnancies resulted in spontaneous abortions. Based on the proband karyotype, his father and half-brother were subjected to cytogenetic analysis, and both showed 46,XY, t(3;6)(q12;q27). After genetic counseling, the proband chose to continue the pregnancy. During the third pregnancy, the subject gave birth to a normal male infant. For parental carriers with balanced chromosomal translocations, natural pregnancy should be considered during genetic counseling.

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Loss in terms of air resistance and bearing friction is an important origin of inertia error that must be compensated in brake dynamometer testing, the acquisition of which has always been a troublesome problem. An indirect method of loss measurement using the speed data under zero pipeline pressure is described in this paper. A mathematical model of the resistance torque or the energy loss is calculated by regression of the collected speed data using statistical software. Error compensation of the two inertia-simulating methods, namely the torque control method and the energy compensation method, is discussed. Experiments using the former method are conducted on an NT11 brake dynamometer, which proves this method to be effective in eliminating inertia error.

Purpose: The aim of this research is to study the trend of pedestrian lower extremity injuries during vehicle-pedestrian collisions. Methods: In this study, pedestrian’s age, collision angle and pedestrian’s position are considered influencing factors. Nine experiments using a novel lower extremity mechanical model are designed with the orthogonal experiment method. Results: Under the same collision angle, collisions in the left and right positions caused more serious tibia injuries than the middle position. As for the collision angle, the tibial injury at +45° is more significant than the tibial injury at −45°, and the injury of oblique collisions is slightly greater than that at 0°. Moreover, tibial injury is more sensitive to research variables than femoral injury. When the collision angle and position are changed, the difference ratio of tibia stress is by 483.2% higher than that of femur stress. The axial force and bending moment of the quadriceps tendon in the left-position collision reach peak values, which are 3.83 kN and 165.98 Nm, respectively. The peak quadriceps tendon axial force is captured with the collision angle of −45°, and the peak quadriceps tendon bending moment is obtained with a collision angle of +45°. Conclusions: The effects of differences in impact position and angle on lower extremity injury in the elderly were analyzed, and the results of this study can be used as a reference for research on lower extremity protection

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