Primary lung LELC is closely associated with Epstein-Bar virus infection but not involved in EGFR mutation pathway. Radical surgery could achieve a good outcome for resectable pulmonary LELC, and regional lymph node status is a vital prognostic factor.

Gefitinib demonstrated significant antitumor activity with a favorable toxicity profile for pretreated Chinese patients with advanced NSCLC. The active mutation of the EGFR kinase domain was strongly associated with response to gefitinib and prolonged overall survival.

No abstract

In the wild type of rice endosperm cell, glutelins and prolamins are synthesized on the respective subdomains of rough endoplasmic-reticulum (ER) and intracellularly compartmentalized into the different storage protein bodies, respectively. Herein, we first report a rice mutation involved in the biogenesis of glutelins and prolamins. A novel mutant for storage proteins was isolated and characterized by the great generation of 57 kD glutelin precursors (proglutelins) and the lacking of 13 kD prolamins. The proteinous alteration was clarified to result from a monogenic mutation with the dosage effect on generation of proglutelins and 13 kD prolamins. This mutation is referred to as GPGG1. A novel ER, the saccular composite-ER, was shown to act in the synthesis of proglutelins and 14 kD prolamins in the mutant. In addition to the composite-ER, the mutant type Golgi, trans-Golgi network, endocytotic protein-storage-vacuole, multivesicular body and lytic vacuole were shown to occur and function in the transfer, exocytosis, endocytosis, delivery, deposition and degradation of storage proteins in the mutant. Moreover, the GPGG1 gene was mapped to a 63.8-kb region of chromosome 12, and a pentatricopeptide repeat-like gene was determined as its candidate gene. Our results reveals that the GPGG1 was involved in the storage protein synthesis and caused the remodeling of endomembrane system for storage protein compartmentation. The candidate gene presumably concerns translation of storage protein mRNAs in rice endosperm cells.