The sensitive subjects were prone to be stimulated by capsaicin to trigger neural and vascular hyper-reactivity. The genetic variation of TRPV1 and the unpleasant sensation demonstrate that TRPV1 play an important role in the pathogenesis of sensitive skin. Our study supports that sensory irritation inhibitors and anti-inflammatory compounds should be considered to be added in cosmetics to reduce the heighted neural and vascular reaction of sensitive skin.
Facial skin in female subjects living in different Asian cities exhibited a wide range of changes and worsening of various biophysical parameters in response to the low temperature and humidity during the winter season as compared with summer.
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