Significance and Impact of the Study: Methicillin-resistant Staphylococcus aureus is the pathogen represents a considerable burden on the healthcare system worldwide, and resistance to nearly all β-lactam antibiotics. For the first time, we evaluated the antibacterial activity and the synergy of the sanguisorbigenin (SGB) combined with β-lactam antibiotics against methicillin-resistant S. aureus. The result indicated that SGB has a potent antibacterial effect and could effectively reverse the sense of β-lactam antibiotics by inhibiting mecA expression and decrease the PBP2a expression. This study has a certain reference value for the development of novel antibacterial agents and antibiotic modulators.
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