This paper studies the decomposition of the time reversal operator (DORT, by the French acronym) technique for microwave breast lesion classification. We apply the finitedifference time-domain (FDTD) method to a realistic numerical breast phantom where lesion-like targets are artificially introduced, and obtain the multistatic data matrix (MDM) for a particular antenna array configuration. Then, the singular value decomposition (SVD) of this matrix is derived for different targets, which represent malignant and benign lesions. We show that the singular value spectrum can assist in classifying these targets as malignant or benign, especially in the case where contrast-enhanced agents can be employed to allow the analysis of differential backscatter data.
Kisspeptin neurons in the arcuate nucleus of the hypothalamus generate GnRH pulses, and act as critical initiators of functional gonadotrophin secretion, and reproductive competency. However, kisspeptin in other brain regions, most notably the posterodorsal subnucleus of the medial amygdala (MePD), plays a significant modulatory role over the hypothalamic kisspeptin population; our recent studies using optogenetics have shown that low frequency light stimulation of MePD kisspeptin results in increased LH pulse frequency. Nonetheless, the neurochemical pathways that underpin this regulatory function remain unknown. To study this, we have utilised an optofluid technology, precisely combining optogenetic stimulation with pharmacological receptor antagonism, to investigate the neurotransmission involved in this circuitry. We have shown that functional neurotransmission of both GABAA and glutamate is a requirement for effective modulation of the GnRH pulse generator by amygdala kisspeptin neurons.
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