Long non-coding RNAs (lncRNAs) have been proven to play important roles in carcinogenesis and development of numerous cancers, but their biological functions in glioblastoma remain largely unknown. In this study, we found that HOXB-AS1 was highly expressed in human glioblastoma tissues and cell lines, and was associated with survival time of patients. Further analysis showed that knock-down of HOXB-AS1 inhibited cell proliferation via inducing S phase cell cycle arrest and suppressed migration and invasion ability of cells. Mechanism study revealed that HOXB-AS1 is mainly located in cytoplasm and functions as competing endogenous RNA via sponging of miR-885-3p. Moreover, inhibition of miR-885-3p antagonized the effects of HOXB-AS1 knock-down and promoted proliferation, migration and invasion of glioblastoma cells. Finally, we found that sponging of miR-885-3p by HOXB-AS1 could further affect the expression of HOXB2. Taken together, we demonstrate that HOXB-AS1/miR-885-3p/HOXB2 axis regulates proliferation, migration and invasion of glioblastoma cells and can serve as a potential biomarker for the malignancy.
Bladder cancer (BCa) is the fourth most common urological malignancy in the world, it has become the costliest cancer to manage due to its high rate of recurrence and lack of effective treatment modalities. As a natural byproduct of cellular metabolism, reactive oxygen species (ROS) have an important role in cell signaling and homeostasis. Although up-regulation of ROS is known to induce tumorigenesis, growing evidence suggests a number of agents that can selectively kill cancer cells through ROS induction. In particular, accumulation of ROS results in oxidative stress-induced apoptosis in cancer cells. So, ROS is a double-edged sword. A modest level of ROS is required for cancer cells to survive, whereas excessive levels kill them. This review summarizes the up-to-date findings of oxidative stress-regulated signaling pathways and transcription factors involved in the etiology and progression of BCa and explores the possible therapeutic implications of ROS regulators as therapeutic agents for BCa. Keywords Reactive oxygen species • Oxidative stress • Bladder cancer • Apoptosis • Therapeutics Abbreviations ALKBH8 Alkylated DNA repair protein alkB homolog 8 ASK1 Apoptosis signal-regulating kinase 1 BCa Bladder cancer Egr-1 Early growth response gene-1 ERK Extracellular signal-regulated kinase FGFR3 Fibroblast growth factor receptor 3 G6PD Glucose-6-phosphate dehydrogenase HDACI Histone deacetylase inhibitor JNK c-JunN-terminal kinase LCA Licochalcone A LTB4R2 Leukotriene B4 receptor 2 gene MIBC Muscle invasive bladder cancer MKPs MAP kinase phosphatases MMP9 Matrix metalloproteinase-9 MT-CYB Mitochondrial cytochrome b NRF2 Nuclear factor erythroid 2-related factor 2 ROS Reactive oxygen species SPARC Serum protein acidic and rich in cysteine TM4SF1 Transmembrane-4-L-six-family-1 VEGF Vascular endothelial growth factor * F.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.