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BackgroundIntegrin expression has been identified as a prognostic factor in non-small-cell lung cancer (NSCLC). This study was aimed at determining the predictive ability of integrins and associated genes identified within the molecular network.Patients and methodsA total of 959 patients with NSCLC from The Cancer Genome Atlas cohorts were enrolled in this study. The expression profile of integrins and related genes were obtained from The Cancer Genome Atlas RNAseq database. Clinicopathological characteristics, including age, sex, smoking history, stage, histological subtype, neoadjuvant therapy, radiation therapy, and overall survival (OS), were collected. Cox proportional hazards regression models as well as Kaplan–Meier curves were used to assess the relative factors.ResultsIn the univariate Cox regression model, ITGA1, ITGA5, ITGA6, ITGB1, ITGB4, and ITGA11 were predictive of NSCLC prognosis. After adjusting for clinical factors, ITGA5 (odds ratio =1.17, 95% confidence interval: 1.05–1.31) and ITGB1 (odds ratio =1.31, 95% confidence interval: 1.10–1.55) remained statistically significant. In the gene cluster network analysis, PLAUR, ILK, SPP1, PXN, and CD9, all associated with ITGA5 and ITGB1, were identified as independent predictive factors of OS in NSCLC.ConclusionA set of genes was identified as independent prognostic factors of OS in NSCLC through gene cluster analysis. This method may act as a tool to reveal more prognostic-associated genes in NSCLC.

Previous research suggested that dominance orientation and authoritarianism may be associated with corruption, but little research has verified this assumption or uncovered its psychological processes. In this article, we examined empirically the relationships between social dominance orientation (SDO), right-wing authoritarianism (RWA) and corrupt intention and explored the mediating role of moral outrage on these relationships. A total of 677 college students participated in the study and completed measures of SDO, RWA, moral outrage and corrupt intention. Our findings demonstrated that both SDO and RWA were positively associated with corrupt intention. Additionally, moral outrage partially mediated the relation between SDO and corrupt intention and fully mediated the relation between RWA and corrupt intention. Specifically, the results indicated that higher SDO or RWA was associated with reduced moral outrage and increased corrupt intention. This implies that the enhancement of morality and moral outrage may inhibit corrupt intention.

Symmetry is a basic geometry property that affects people’s aesthetic experience in common ways across cultures and historical periods, but the origins of the universal preference for symmetrical patterns is not clear. We assessed four-year-old children’s and adults’ reported aesthetic preferences between symmetrical and asymmetrical visual patterns, as well as their spontaneous attentional preferences between the patterns. We found a striking dissociation between these two measures in the children: Children looked longer at the symmetrical patterns, relative to otherwise similar but asymmetrical patterns, but they showed no explicit preference for those patterns. These findings suggest that the human’s aesthetic preferences have high postnatal plasticity, calling into question theories that symmetry is a “core feature” mediating people’s aesthetic experience throughout life. The findings also call into question the assumption, common to many studies of human infants, that attentional choices reflect subjective preferences or values.

Corruption has a wide range of corrosive effects on societies, but it is widespread throughout the world. There is a question, however, as to whether corruption is endorsed as an outcome of a legitimate hierarchy and meritocracy. To address this issue, the present study examines the associations between meritocratic ideology and the indicators of corruption by performing two empirical studies with correlational and experimental designs. In Study 1, all variables were measured with scales, and the results demonstrated that meritocratic ideologies were negatively associated with corruption perception but positively associated with corrupt intention. In Study 2, meritocratic ideology was manipulated, and the results demonstrated that compared with the low meritocratic-ideology condition, the participants primed by the high meritocratic-ideology condition reported a lower corruption perception but higher corrupt intention. In both studies, the findings suggest that the meritocratic ideology that motivates people to maintain and bolster the current hierarchical structure and meritocracy leads to the endorsement of corruption. The present study explores the roles of meritocratic ideology in the perception and intention of corruption, extends the scope of the predictive power of system justification theory to corruption beyond mere injustice-related aspects of disadvantage, and also provides suggestions for interpreting and fighting against corruption.

BackgroundSarcoptic mange caused by the mite Sarcoptes scabiei is a worldwide disease affecting both humans and animals. Here we report the molecular characterization and evaluation of a recombinant S. scabiei tropomyosin (SsTm) protein in a vaccination trial in rabbits.MethodsThe full-length cDNA was cloned in a bacterial pET vector, and the recombinant protein was expressed in BL21 (DE3) cells and purified. Using specific rabbit antiserum, tropomyosin was localized immunohistochemically in mite tissue sections. Vaccination trials with the recombiant SsTm was carried out in New Zealand rabbits.ResultsThe full-length open reading frame (ORF) of the 852 bp cloned gene from S. scabiei encodes a 32.9 kDa protein. The amino acid sequence showed 98.94%, 97.89% and 98.59% homology to Dermatophagoides farina and Dermatophagoides pteronyssinus group 10 allergens and Psoroptes ovis tropomyosin, respectively. Tropomyosin was localized immunohistochemically in mite tissue sections mainly in the mouthparts, legs and integument of the epidermis. The predicted cross-reactivity of SsTm indicated that it is an allergenic protein. While vaccination with the recombiant SsTm resulted in high levels of specific IgG (P < 0.01), a low IgE antibody response and no significant protection against S. scabiei challenge were observed. After challenge, specific IgG levels remained significantly higher than the control (P < 0.01), while changes of total IgE levels were not significant (P > 0.05). However, the lesion areas in the vaccination group decreased at the end of the experiment compared with controls.ConclusionsAlthough vaccination with recombinant SsTm did not efficiently control sarcoptic mange in rabbits, the immunogenic properties of tropomyosin suggest it may be developed as a vaccine with alternative adjuvants or delivery methods.

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