It has been suggested that the altered function of reward and punishment is an important vulnerability factor leading to the development of drug use disorders. Previous studies have identified evidence of neurophysiological dysfunction in the reward process of individuals with substance use disorders. To date, only a few event-related potential (ERP) studies have examined the neural basis of reward and punishment processing in women with methamphetamine (MA) use disorders. The current ERP research aims to investigate the neurophysiological mechanisms of reward and punishment in women with MA use disorder using a monetary incentive delay task. Nineteen women with MA use disorder (MA group) and 20 healthy controls (HC group) were recruited in this study. The behavioral data showed that the reaction time (RT) was faster and the response accuracy (ACC) was higher for the potential reward and punishment conditions compared to neutral conditions. During the monetary incentive anticipation stage, the Cue-P3, and stimulus-preceding negativity (SPN) were larger in the MA group than in the HC group. The SPN under the potential reward condition was larger than that under the neutral condition in the MA group but not in the HC group. During the monetary incentive consummation stage, the feedback-related negativity and feedback P3 (FB-P3) following positive feedback were significantly larger than negative feedback in the potential reward condition for the HC group, but not for the MA group. However, the FB-P3 following negative feedback was significantly larger than positive feedback in the potential punishment condition for the MA group, but not the HC group. The results suggest that women with MUD have stronger expectations of generic reward and stronger response of generic harm avoidance, which could be targeted in designing interventions for women with MA use disorder.
Development occurs through the process of setting and working toward goals, in which individuals are often working toward multiple goals that are likely to conflict with one another. Although motivation theories hold that goal conflict is a kind of potential stress that may damage individuals’ mental health and wellbeing, the empirical research results on the relationship between goal conflict and wellbeing are quite different. There may be unknown factors affecting the relationship between the two. Against this background, we conducted the exploration of the relationship between goal conflict and life satisfaction, mainly by analyzing the moderated mediating effect of mixed emotions and construal level. The results showed that the goal conflict did not directly affect life satisfaction (β = −0.01, p > 0.5) but indirectly influenced life satisfaction through mixed emotions (β = −0.17, p < 0.001). The construal level moderated the relationship between mixed emotions and life satisfaction (β = −0.08, p < 0.01), and the higher construal level will predict higher life satisfaction especially when mixed emotions were low (M − SD) or medium (M). Therefore, the hypothesis of moderated mediating effect is verified, and we can draw the following conclusions: (1) Goal conflict does not necessarily impair life satisfaction. (2) Goal conflict impairs life satisfaction conditional on the fact that it triggers mixed emotions. Since mixed emotions are often accompanied by feelings of ambivalence and discomfort, they reduce the individual’s evaluation of life satisfaction. (3) In the path of goal conflict reducing life satisfaction through mixed emotions, the higher construal level mitigates the adverse effects of mixed emotions to some extent.
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