Background:
Oleanolic acid (OA) is a ubiquitous product of triterpenoid compounds. Due
to its inexpensive availability, unique bioactivities, pharmacological effects and non-toxic properties,
OA has attracted tremendous interest in the field of drug design and synthesis. Furthermore, many OA
derivatives have developed for ameliorating the poor water solubility and bioavailability.
Objective:
Over the past few decades, various modifications of the OA framework structure have led
to the observation of an enhancement in bioactivity. Herein, we focused on the synthesis and
medicinal performance of OA derivatives modified on A-ring. Moreover, we clarified the relationship
between structures and activities of OA derivatives with different functional groups in A-ring. The
future application of OA in the field of drug design and development also was discussed and inferred.
Conclusion:
This review concluded the novel achievements that could add paramount information to
the further study of OA-based drugs.
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