Segmentation of brain tissues from magnetic resonance (MR) images plays a crucial role in medical image processing. In this paper, we propose an automatic unsupervised segmentation method integrating wavelet transform with self-organizing map for brain MR image. Firstly, a multi-dimensional feature vector is constructed based on the intensity, the low-frequency subband of wavelet transform and spatial position information. Then, an adaptive growing self-organizing tree map (AGSOTM) is presented, which adaptively captures the complicated spatial layout of the individual tissues, and overcomes the problem of overlapping grey-scale intensities for different tissues. The proposed method is validated by extensive experiments using both simulated and real T1-weighted MR images, and compared with other algorithms.
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