Abstract:Neuronal activity promotes high-grade glioma (HGG) growth. An important mechanism mediating this neural regulation of brain cancer is activity-dependent cleavage and secretion of the synaptic molecule and glioma mitogen neuroligin-3 (Nlgn3), but the therapeutic potential of targeting Nlgn3 in glioma remains to be defined. We demonstrate a striking dependence of HGG growth on microenvironmental Nlgn3 and determine a targetable mechanism of secretion.Patient-derived orthotopic xenografts of pediatric glioblastoma, diffuse intrinsic pontine glioma peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission.The copyright holder for this preprint (which was not . http://dx.doi.org/10.1101/153122 doi: bioRxiv preprint first posted online Jun. 21, 2017; derived neurotrophic factor (Bdnf) and neuroligin-3 (Nlgn3) into the tumor microenvironment 1 .