Highlights
Exosomal miRNAs were derived from cancer cell lines and patient's blood.
Exosomal miR-193a was increased in peritoneal metastasis of colorectal cancer.
Exosomal let-7g was decreased in peritoneal metastasis of colorectal cancer.
Decreased miR-193a and increased let-7g were seen as cancer progression indicator.
Decreased miR-193a and increased let-7g were involved in patient survival rate.
Many-core processor based systems gain popularity in high-performance parallel embedded applications. Estimating memory bandwidth requirement, i.e. external memory bandwidth, given various cache size for target parallel applications requires a prohibitively large simulation time. In this work, we propose an analytical model to quickly estimate the memory bandwidth for a given cache size and help exploring trade-offs between cache sizes and memory bandwidth requirement. We model the stochastic behavior of cache misses for a single cache as a random process. Using central limit theorems for identically or non-identically distributed random processes, we accurately estimate the collective cache misses from hundreds of processor cores and thus the total memory bandwidth requirement for the whole system. The results show that our model improves a speed of simulation time up to 200.4 times for 200 cores whereas its estimated results achieve less than 0.01% difference from the simulated ones for 200 cores in terms of accuracy.
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