We have demonstrated the efficacy of transtympanic lactated Ringer's solution and N-acetylcysteine in the prevention of cisplatin ototoxicity using a guinea pig model. The possible mechanisms for the high efficacy of lactated Ringer's solution are discussed in detail.

Ciprodex otic augmented with NAC seems to have considerable efficacy against otherwise refractory ear infections. This technique may prove to be a simple and powerful option for the treatment of difficult ear infections.

Cochlear implantation is being performed in increasingly younger children. We present a retrospective cohort of 19 patients with 23 ears implanted under 18 months of age. The mean age at implantation was 11.9 months, with the youngest being 6.8 months. The facial recess was narrow in nine ears (39%), including all premature infants. An inferiorly located stapedius tendon was sectioned in seven ears (30%) to facilitate round window access. Countersinking of the receiver-stimulator required dural exposure in 22 ears (96%). The receiver-stimulator was secured with sutures in 15 ears (65%) and within a tight pocket in eight ears (35%). Tympanostomy tubes were placed in 10 ears (43%). Cochlear implantation in very young children frequently necessitates modified surgical techniques.

Cochlear implantation is being performed in increasingly younger children. We present a retrospective cohort of 19 patients with 23 ears implanted under 18 months of age. The mean age at implantation was 11.9 months, with the youngest being 6.8 months. The facial recess was narrow in nine ears (39%), including all premature infants. An inferiorly located stapedius tendon was sectioned in seven ears (30%) to facilitate round window access. Countersinking of the receiver‐stimulator required dural exposure in 22 ears (96%). The receiver‐stimulator was secured with sutures in 15 ears (65%) and within a tight pocket in eight ears (35%). Tympanostomy tubes were placed in 10 ears (43%). Cochlear implantation in very young children frequently necessitates modified surgical techniques. Copyright © 2006 John Wiley & Sons, Ltd.

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