A bstractT h is p h ase 1 clin ical trial tested th e safety o f intram uscu lar g en e transfer by using naked plasm id D N A en co ding th e gene for V E G F, and analyzed the potential th erapeutic benefits in patien ts w ith severe periph eral arterial disease (P A D ). This study w as an op en -labeled, d oseescalatin g , sin g le-cen ter trial o n n in e m ale p atients w ith severe debilitating P A D w ho had not resp ond ed to conventional therapy.
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