In the course of some experiments on the physiology of the liver of the dog, we observed that ligation of the hepatic artery caused death of the animals in convulsions. Previous investigators'* 2s observed death in convulsions in animals after complete circulatory exclusion of the liver. Mann and Magath4 found that after complete hepatectomy their dogs died in hypoglycemic convulsions. We, thewfore, undertook the study of the relation of the blood sugar level to the convulsive seizure following ligation of the hepatic artery.There was a remarkable constancy in the results obtained. After coming out of the anesthetic, the dogs appeared normalwalked, ran, barked, drank water and excreted normal amounts of urine and feces. The dogs remained in this apparently normal state from 15 to 50 hours, following which they became drowsy, listless, and unresponsive. Pinching or pricking did not call forth any response. The animals refused food and water. During this stage uccasional fibrillary twitches were observed. Then (within 1 to 2 hours) they manifested symptoms of hyperirritability, hyper-reflexia and a sudden onset of generalized clonic convulsions followed by tonic spasms, retraction of the neck, respiratory paralysis, an occasional sharp yelp, and death. This general seizure usually lasted from 2 to 5 minutes.
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