The main causes of skin infections is Propionibacterium acnes. The use of antibiotics can be an effective treatment of acne for example: clindamycin. Lime was a plant that is used as a treatment for acne's inhibition. The lemon part often used to treat acne was the juice. The purpose of this study was to determine the activity of lime juice in inhibiting the growth of Propionibacterium acnes and to determine the minimum inhibitory concentration of lime juice against Propionibacterium acnes. The study used lime juice with various concentrations of 100%, 50%, 25%, and 12.5% on the growth of Propionibacterium acnes bacteria using the disc diffusion method. The data obtained were tested for normality Kolmogorov-Smirnov and homogeneity test. Then the Kruskall Wallis and Mann-Whiteney test were performed. Based on this study, lime juice was proven to be able to inhibit the growth of Propionibacterium acnes bacteria. The inhibition zone with the highest average concentration was at 100% concentration, which was 18.7 mm and the smallest average inhibition zone was found at a concentration of 12.5%, which was 11.5 mm. The results of the statistical test showed a significant difference with p-value= 0.029 between the positive control and the variation of the sample concentration
Diabetes Melitus merupakan salah satu kondisi yang sering ditemukan. Oleh karena itu, hendaklah tatalaksana dan pemilihan pengobatan antidiabetes menjadi perhatian di instalasi-instalasi pengadaan terapi sebagai penyedia layanan kesehatan primer, seperti rumah sakit. Penelitian ini disusun untuk mengkaji pemilihan penggunaan obat antidiabetik oral (ADO) pada pasien umum di instalasi rawat jalan rumah sakit swasta di Samarinda. Penelitian ini dilakukan dengan menggunakan rancangan deskriptif dimana data dikumpulkan secara retrospektif. Data diambil dari resep pasien umum di instalasi rawat jalan RS swasta di Samarinda pada bulan Juni 2022. Hasil penelitian menunjukkan pada bulan Juni 2022 terdapat 8,30% penggunaan terapi ADO tunggal dan 91,70% merupakan terapi kombinasi. Dari hasil penelitian diperoleh obat ADO yang diresepkan adalah golongan biaguanida (Metformin); sulfonilurea (glimepiride, gliclazide, gliquidone); acarbose; dan penghambat DPP-4 (Vidagliptin). Secara keseluruhan, terapi ADO dengan kombinasi menggunakan dua (2) obat ditemukan paling banyak dalam penelitian ini, sebanyak 182 kasus (75,52%). Kombinasi yang mendominasi adalah kombinasi antara metformin dan glimepiride, sebanyak 140 kasus (58,09 %).
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