BackgroundMercury can be very toxic to human health even at low dose of exposure. Artisanal small-scale miners (ASGMs) use mercury in gold production, hence are at risk of mercury-induced organ dysfunction.AimWe determined the association between mercury exposure, thyroid function and work-related factors among artisanal small-scale gold miners in Bibiani- Ghana.MethodWe conveniently recruited 137 consenting male gold miners at their work site in Bibiani-Ghana, in a comparative cross-sectional study. Occupational activities and socio-demographic data of participants were collected using a questionnaire. Blood sample was analysed for total mercury and thyroid hormones.ResultsOverall, 58.4% (80/137) of the participants had blood mercury exceeding the occupational exposure threshold (blood mercury ≥5μg/L). T3(P<0.0001) and T4(P<0.0001) were significantly reduced among the exposed group compared to the non-exposed. TSH showed no significant variation between the exposed and non-exposed groups. Longer work duration (≥5years), gold amalgamation, gold smelting and sucking of excess mercury with the mouth were associated with increased odds of mercury exposure. Blood mercury showed negative correlation with T3(r = -0.29, P<0.0001), and T4(r = -0.69, P<0.0001) and positive correlation with work duration (r = 0.88, P<0.001). Even though a positive trend of association between blood mercury and TSH levels was recorded, it was not significant (r = 0.07, P = 0.4121)ConclusionSmall scale miners in Bibiani are exposed to mercury above the occupational threshold which may affect thyroid hormone levels.

Background: Diabetes mellitus is a metabolic chronic disease affecting a majority of adults with associated complications. The non-compliance to the anti-diabetic medication has become a global challenge to achieving optimal glucose control among Diabetes Type 2 patients. This study, therefore, sought to determine the self-care practices and drivers of anti-diabetic type 2 medication non-compliance among patients accessing health care at Volta River Authority Hospital in Akosombo of Ghana. Methods: A quantitative study and descriptive cross-sectional design employed a simple random sampling technique to recruit 220 diabetes type 2 patients by administering a structured questionnaire face to face to gather data. Data were analysed with the help of Stata 16. A descriptive and inferential statistic was conducted to determine the relationship between the dependent and independent variables at a 95% confidence interval and a p-value of less than 0.05 was considered statically significant. Results: The study found that non-adherence to anti-diabetic medication was 45.5%. Most of the participants had inadequate (52.3%) self-care practices. Age of participants (40-49) years [p=0.0001], Female [p=0.004] significantly influenced non-compliance. Being Single [p=0.001] and presence of comorbidity [p=0.001] also associated with medication non-compliance. Conclusion: The study concluded that a significant proportion of diabetes type 2 patients do not comply with anti-diabetic medication and this was influenced by inadequate self-care practices, age, female, comorbidity and being single. The study recommended the intensification of awareness creation on complications of non-complying to anti-diabetic medication and education on self-care practices through mass media. Further studies are required to identify the possible predictors of inadequate self-care practices that influence anti-diabetic medication non-compliance.