Controversy continues over the effects of calcium antagonists on glucose homeostasis and cardiac function, particularly in diabetics. Changes in blood pressure, exercise tolerance, insulin secretion and glycaemic control were studied therefore in 12 insulin-treated hypertensive diabetics with varying endogenous insulin reserve who were given nifedipine 20 mg twice daily for six weeks. Six hypertensive diabetic subjects off all antihypertensive medication served as controls.Glycaemic control and blood pressure did not alter in the control group over the six week period. In the nifedipine-treated group blood pressure levels remained significantly improved at six weeks with systolic pressure falling from 178 ±24 to 158 ±20 (p
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