Whether transfused blood corpuscles live and function for any considerable length of time, or whether the beneficial results that have been observed to follow transfusion, outside the purely mechanical part of increasing the bulk of the depleted blood, are due to a stimulating effect on the hemopoietic function by the product of the broken down corpuscles is still an open question (Archibald, Crile, Hunter, Kimpton, Primrose, Robertson and Watson).Marfels and Moleschott (1856) and Brown-Sequard (1867) studied the question of the length of life of blood corpuscles b y injecting. nucleated corpuscles (bird and frog)into animals having non-nucleated corpuscles, and watching for the disappearance of the nucleated corpuscles from the circulation of the transfused animal. It is now known that these results have no bearing on the question, as it was not blood destruction that was being studied but the elimination of foreign protein. The same objection holds good for any attempt to stain blood corpuscles with so called vital stain and to reinject them, since there is no stain known that will ho]d without destroying the living quality of the corpuscles; therefore, in the stained corpuscle we are again dealing with a foreign body capable of more or less rapid removal than transfused blood.Thus far the only satisfactory direct methods of attacking the problem of the length of life of transfused corpuscles have been those involving the study of the changes of the erythrocyte count following transfusion. Extensive work along this line, done on animals by Ward-Muller, Quinck, yon Ott, and Hunter, was reviewed by Hunter in 1885 and 1886. Ward-Muller transfused dogs and produced 267 on
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Group IV transfused blood in a recipient of unlike group is eliminated by a blood-destroying activity of the body.
This blood-destroying activity is periodic both in men and women, and in women coincident with menstruation.
The elimination of the transfused blood probably takes place as part of a period of blood-destroying and blood-producing activity of the body, although direct evidence to this effect is so far lacking.
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