Traditional fluorescent peptide chemical syntheses hinge on the use of limited fluorescent/dye-taggable unnatural amino acids and entail multiple costly purifications. Here we describe a facile and efficient protocol for in...
Epstein‐Barr virus (EBV) is a common human‐infected virus related to many diseases and cancers. Recently, some peptides have been found to serve targeting and therapeutic roles by inhibiting EBNA1, an oncoprotein of the EBV. We herein report the conjugation of the EBNA1‐targeting peptides and porphyrins which can bring synergistic effects by both introducing more specific treatments (photodynamic therapy) and improving the biocompatibility of the photosensitizer and the peptides. One of our compounds exhibited significant photo‐cytotoxicity where the Lethal Concentration 50 (LC50)=6.1 μM in EBV‐positive cells. Besides, in vitro cell imaging and co‐staining can also be achieved simultaneously and suggested the binding inside nucleus.
A low-molecular-weight,
solid CO surrogate that only requires a
low-power LED for activation to release 2 equiv of CO is reported.
The surrogate can be universally implemented in various palladium-catalyzed
carbonylative transformations. It is also compatible with protocols
that employ blue-light to activate conventionally inaccessible substrates
such as nonactivated alkyl halides. Furthermore, we demonstrate that
the photolabile CO-releasing scaffold can be installed into polymeric
materials, thereby creating new materials with CO-releasing capabilities.
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