This investigation seeks to explore the effectiveness of alternative approaches to supply chain management for developing the base of the pyramid (BoP) community. Using case research methodology, we investigate the issue of supply chain alignment when the supply base consists of BoP producers. We consider the handloom supply chains in Odisha, India, as the context of our analysis. The study analyzes the supply chains of four handloom retailers. The retailers represent cooperative and private organizational systems with varied levels of operational integration. In light of the insights from these case studies, we theorize factors contributing to operational cost‐effectiveness and conceptualize approaches and considerations for improving the BoP community. Specifically, we clarify the usefulness of alternative supply chain alignment practices in promoting efficiency, innovation, and equitability among the BoP constituents and advance a set of propositions linking the motivations, strategies, practices, and performance in handloom supply chains. Limitations, theoretical and managerial contributions, and future research directions are discussed.