No abstract

Thiouracil is selectively incorporated into melanotic murine melanomas during melanin synthesis. This selectivity makes thiouracil a likely vehicle for boron in the diagnosis and therapy of melanoma. Several synthetic routes to thiouracils bearing an alkyl decacarboranyl group attached to various positions on the ring have been investigated. The successful syntheses of three new alkynyl thiouracils and the conversion of one of them into a carboranyl thiouracil are described.

Evaluation of outcome measures can provide policymakers with valuable information on the effectiveness of psychiatric rehabilitation. Two specific challenges in collecting outcome measures for psychiatric rehabilitation programs are heterogeneity of outcomes and difficulty with follow-up. These two challenges were illustrated in the process of evaluating Rose Hill Center, a rural residential psychiatric rehabilitation program. The original design was to conduct interviews with former residents and family members and verify healthcare utilization. The difficulty of locating people and their reluctance to participate conspired to lower the follow-up rates. The design was modified to improve the follow-up rate but decrease the details of specific outcomes. The results showed a high but biased follow-up rate, with more information obtained for people who graduated from the program. The residents with planned discharge showed excellent outcomes in terms of living situation, working situation, healthcare utilization, and low severity of current symptoms. High compliance with medication spoke to the program's philosophy of including the residents in the decision-making process. The dual challenges of heterogeneity of outcomes and difficulty in follow-up that limit efforts to document the value of psychiatric rehabilitation are discussed.

No abstract

THis title is to be preferred to "deafness due to shiell shock" for several reasons. The word "slhock" lhas a varied significance. To the neurologist it conveys miiany ideas; tllus von Monako* distinguishes several varieties of shock-surgical slhock, psycllical slhock, apoplectic slhocl, commotio cerebri, diasellisis. Eveni in its best recognized form, surgical shock, tlle pliysiological meelanismii wh-llich has been interfered with to prodtice the symlptormis is unknown. The title clhosen will, I lhope, do away with