OBJETIVO: Estudar a obesidade grau III ou grave, identificando o perfil demográfico, clínico e as doenças de maior ocorrência, em pacientes atendidos na consulta de enfermagem, candidatos a cirurgia bariátrica do Núcleo do Hospital Universitário da Universidade Federal de Mato Grosso do Sul. MÉTODOS: Trata-se de um estudo descritivo, com análise dos registros em 252 prontuários dos pacientes atendidos no Programa de Cirurgia Bariátrica do Núcleo do Hospital Universitário da Universidade Federal de Mato Grosso do Sul, entre 2004 a 2007. RESULTADOS: A prevalência crescente de sobrepeso e obesidade está associada a doenças crônicas relacionadas à dieta (comorbidades). Dos 252 pacientes atendidos 80,15% eram do sexo feminino; a média da idade foi de 36,07±10,16 anos; quanto à etnia 86,53% eram brancos, 8,57% pardos e 4,90% negros; houve predomínio das comorbidades: hipertensão arterial (63,49%), dispnéia (55,56%), varizes de membros inferiores (45,63%) e depressão (36,51%). CONCLUSÃO: observa-se que a doença de maior ocorrência na obesidade é a hipertensão arterial, devendo o paciente ser acompanhado por uma equipe multidisciplinar.
Acute renal failure (ARF) is an extremely important public health issue in need of
novel therapies. The present study aimed to evaluate the capacity of mesenchymal stem
cell (MSC) therapy to promote the improvement and recovery of renal function in a
preclinical model. Wistar rats were used as the experimental model, and our results
show that cisplatin (5mg/kg) can efficiently induce ARF, as measured by changes in
biochemical (urea and creatinine) and histological parameters. MSC therapy performed
24h after the administration of chemotherapy resulted in normalized plasma urea and
creatinine levels 30 and 45d after the onset of kidney disease. Furthermore, MSC
therapy significantly reduced histological changes (intratubular cast formation in
protein overload nephropathy and tubular hydropic degeneration) in this ARF model.
Thus, considering that current therapies for ARF are merely palliative and that MSC
therapy can promote the improvement and recovery of renal function in this model
system, we suggest that innovative/alternative therapies involving MSCs should be
considered for clinical studies in humans to treat ARF.
Purpose: To compare the use of a new cyanoacrylate-based surgical glue and suture with separate points in skin wounds closure. Methods: Thirty-six rats were subjected to a 4cm dorsal longitudinal incision. Twelve were subjected to simple suture with polyamide 6-0, 12 rats underwent wall synthesis using Dermabond® and 12 was performed cutaneous synthesis with N-2-Butyl-Cyanoacrylate. Twelve of each group was euthanized on the seventh postoperative day, their blood was taken to biochemical tests and a layer of skin and subcutaneous tissue surrounding the surgical scar was randomly divided in two segments, to the submission of tension tests and to histological study. Results: There were no significant difference between groups (p>0.05). In the soft dermis there was more type I collagen production in group I (p<0.05), group II and III was similar re-sults (p>0.05). In the compact dermis, all 3 groups showed similar results (p>0.05). The biomechanical study was similarity between the glue groups (p>0.05) but the group III proved to be different from the others having a higher resistance (p>0.05). Conclusion: This glue does not cause any inflammation or kidney and hepatic toxicity. Polyamide sutures are more resistant and the glue should be used alone only in less tension are-as.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.