Product design is one of the most important sectors influencing global sustainability, as almost all the products consumed by people are outputs of the product development process. In particular, early design decisions can have a very significant impact on sustainability. These decisions not only relate to material and manufacturing choices but have a far-reaching effect on the product’s entire life cycle, including transportation, distribution, and end-of-life logistics. However, key challenges have to be overcome to enable eco-design methods to be applicable in early design stages. Lack of information models, semantic interoperability, methods to influence eco-design thinking in early stages, measurement science and uncertainty models in eco-decisions, and ability to balance business decisions and eco-design methodology are serious impediments to realizing sustainable products and services. Therefore, integrating downstream life cycle data into eco-design tools is essential to achieving true sustainable product development. Our review gives an overview of related research and positions early eco-design tools and decision support as a key strategy for the future. By merging sustainable thinking into traditional design methods, this review provides a framework for ongoing research, as well as encourages research collaborations among the various communities interested in sustainable product realization.

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The issue of environmental sustainability, which is unprecedented in both magnitude and complexity, presents one of the biggest challenges faced by modern society. Engineers, including mechanical engineers, can make significant contribution to the development of solutions to this problem by designing products and processes that are more environmentally sustainable. It is critical that engineers take a paradigm shift of product design i.e. from cost and performance centered to balance of economic, environmental, and societal consideration. Although there have been quite a few design for environment (DfE, or ecodesign) tools developed, so far these tools have only achieved limited industrial penetration: they are either too qualitative/subjective to be used by designers with limited experiences, or too quantitative, costly and time consuming and thus cannot be used during the design process specially during the early design stage. This paper develops a novel, semi-quantitative ecodesign tool that targets specially on early design process. The new tool is a combination of environmental life cycle assessment, working knowledge model, and visual tools such as QFD, functional-component matrix, and Pugh chart. Redesign of staplers is selected as a case study to demonstrate the use of the proposed tool. Efforts are on going to confirm that the new design generated using this new tool does have improved environmental performance.

Polo-like kinases (Plk1-4) are emerging as an important class of proteins involved in many aspects of cell cycle regulation and response to DNA damage. Here, we report the cloning of a fifth member of the polo-like kinase family named Plk5. DNA and protein sequence analyses show that Plk5 shares more similarities with Plk2 and Plk3 than with Plk1 and Plk4. Consistent with this observation, we show that mouse Plk5 is a DNA damage inducible gene. Mouse Plk5 protein localizes predominantly to the nucleolus, and deletion of a putative nucleolus localization signal (NoLS) within its N-terminal moiety disrupts its nucleolar localization. Ectopic expression of Plk5 leads to cell cycle arrest in G1, decreased DNA synthesis, and to apoptosis, a characteristic it shares with Plk3. Interestingly, in contrast to mouse Plk5 gene, the sequence of human Plk5 contains a stop codon that produces a truncated protein lacking part of the kinase domain.