This concept of the mechanism of reaction is supported by the results in perchloric acid solution. Sherrill, et al.,b have shown that no complex is formed in cerium (IV) perchlorate. Under such conditions the observed reaction should be essentially the termolecular reaction (2). This would explain why the rate is greater in perchloric acid (Fig. 2), but reaction is still not instantaneous.
The pharmacological activity and low toxicity of sulfapyrimidine2 have led us to continue3 the preparation of a number of higher homologs and related derivatives, some of which we wish to describe at this time. Five of the requisite substituted 2-aminopyrimidines were prepared by refluxing the appropriate hydroxymethylene ketones with guanidine carbonate in alcohol.4
R-C=0Na R-C=0
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