Psychological stress has been shown to affect immune system status and function, but most studies of this relationship have focused on acute stress and/or laboratory situations. The present study compared total numbers of leukocytes and lymphocyte subpopulations (determined by flow cytometry) and antibody titers to latent and nonlatent viruses among a group of chronically stressed individuals living near the damaged Three Mile Island (TMI) nuclear power plant with those of a demographically comparable control group. Urinary catecholamine and cortisol levels were also examined. Residents of the TMI area exhibited greater numbers of neutrophils, which were positively correlated with epinephrine levels. The TMI group also exhibited fewer B lymphocytes, T-suppressor/cytotoxic lymphocytes, and natural killer cells. Antibody titers to herpes simplex were significantly different across groups as well, whereas titers to nonlatent rubella virus as well as IgG and IgM levels were comparable.
Effects on sexual arousal of unemployment and acute stress were studied in men. Ten unemployed (high-chronic-stress) and 9 employed (low-chronic-stress) men were exposed to two erotic videotapes in the laboratory. Acute stress was induced by telling the men that they would have to give a talk on their own sexual behavior and fantasies. Half the men were told about the talk before seeing either erotic tape, the other half were told in between the two erotic tapes. Cardiovascular measures confirmed the stressful nature of this manipulation. Results showed that the unemployed men achieved less penile tumescence than the employed men when stressed prior to erotic stimulation. Presentation of the stressor between the erotic videotapes (after sexual arousal occurred) produced no differences between the employed and unemployed men. These results suggest that impairment of erection occurs as a result of a combination of chronic and acute stress.
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